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> Protein (NX_Q8NAV1)
Protein (NX_Q8NAV1)
Protein
Gene SymbolPRPF38A to neXtProt (NX_Q8NAV1)
DescriptionPre-mRNA-splicing factor 38A
Chromosome1
Location1p32.3 (52870236 ~ 52886511) to Ensembl
Sequene Features : Isoforms 2, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.poly(A) RNA binding .precatalytic spliceosome
.nuclear membrane
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 36 5
2014-09-19protein level
2 28 5
2014-05-27protein level
2 28 10
2014-02-25protein level
2 28 10
2013-12-09protein level
2 20 10
2013-11-01protein level
2 20 9
2013-09-12protein level
2 20 10
2013-08-17protein level
2 20 10
2013-07-15protein level
2 9 9
2013-06-11protein level
2 9 9
2013-02-12protein level
2 4 28
2012-12-20protein level
2 4 28
2012-10-30protein level
2 4 28
2012-10-07protein level
2 4 15
2012-08-24protein level
2 4 15
2012-07-28protein level
2 4 15
2012-06-08protein level
2 5 15
2012-05-07protein level
2 2 15
2012-04-10protein level
2 2 15
2012-01-13protein level
2 2 15
2011-12-20protein level
2 2 15
2011-11-11protein level
2 2 13
2011-08-23protein level
2 2 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NAV1-1
12 0 0 37453.2747
NX_Q8NAV1-2
1 0 0 15453.0439
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715374,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-715374,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
3 EBI-715374,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
4 EBI-715374,EBI-8464037 JMJD6  
  .histone H4-R3 demethylation
.histone H3-R2 demethylation
.retina development in camera-type eye
  + 15 more...
.peptidyl-lysine 5-dioxygenase activity
.identical protein binding
.histone demethylase activity (H4-R3 specific)
  + 5 more...
.plasma membrane
.nucleolus
.nucleoplasm
.nucleus
5 EBI-715374,EBI-539478 SRPK1  
  .regulation of mRNA processing
.regulation of mRNA splicing, via spliceosome
.innate immune response
  + 9 more...
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.nuclear matrix
.plasma membrane
.endoplasmic reticulum
  + 3 more...
6 EBI-715374,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood40
bone41
bone marrow143
brain57
cervix61
connective tissue20
embryonic tissue14
eye23
heart22
intestine21
kidney52
liver24
lung23
lymph22
lymph node77
mammary gland79
mouth45
muscle9
ovary59
pancreas9
pharynx196
placenta24
prostate52
skin18
spleen37
stomach20
testis57
thymus87
thyroid21
trachea57
uterus51
vascular19
Health State
TissuesTPM*
normal33
breast (mammary gland) tumor118
cervical tumor86
chondrosarcoma60
gastrointestinal tumor25
germ cell tumor60
glioma102
head and neck tumor52
kidney tumor29
leukemia74
liver tumor41
lung tumor29
lymphoma13
non-neoplasia10
ovarian tumor52
pancreatic tumor9
primitive neuroectodermal tumor of the CNS86
prostate cancer38
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult38
embryoid body14
blastocyst16
neonate32
fetus26
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.2
adrenal gland13.3
appendix23.3
bone marrow26.9
cerebral cortex13.8
colon20.9
duodenum16.2
esophagus16
gallbladder13.6
heart muscle10
kidney13.7
liver8.8
lung15.7
lymph node29.3
ovary24.9
pancreas7.7
placenta19.5
prostate17.1
salivary gland12.3
skin13.8
small intestine19.5
spleen20
stomach17.4
testis23.8
thyroid gland17.5
urinary bladder16.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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