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> Protein (NX_Q8NB12)
Protein (NX_Q8NB12)
Protein
Gene SymbolSMYD1 to neXtProt (NX_Q8NB12)
DescriptionHistone-lysine N-methyltransferase SMYD1
Chromosome2
Location2p11.2 (88367299 ~ 88412906) to Ensembl
Sequene Features : Isoforms 1, Variants 112, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.positive regulation of myoblast differentiation
.skeletal muscle cell differentiation
  + 4 more...
.metal ion binding
.histone-lysine N-methyltransferase activity
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 112 0
2014-09-19protein level
1 89 0
2014-05-27protein level
1 89 0
2014-02-25protein level
1 87 0
2013-12-09protein level
1 72 0
2013-11-01protein level
1 66 0
2013-09-12protein level
1 66 0
2013-08-17protein level
1 66 0
2013-07-15protein level
1 50 0
2013-06-11protein level
1 50 0
2013-02-12protein level
1 27 0
2012-12-20protein level
1 26 0
2012-10-30protein level
1 30 0
2012-10-07protein level
1 30 0
2012-08-24transcript level
1 28 0
2012-07-28transcript level
1 28 0
2012-06-08transcript level
1 21 0
2012-05-07transcript level
1 21 0
2012-04-10transcript level
1 21 0
2012-01-13transcript level
1 6 0
2011-12-20transcript level
1 6 0
2011-11-11transcript level
1 6 0
2011-08-23transcript level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NB12-1
20 0 0 56579.7149
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8463848,EBI-2880253 MYH7B  
  .N/A .ATP binding
.motor activity
.myosin filament
.membrane
2 EBI-8463848,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
3 EBI-8463848,EBI-1042898 ADSS  
  .cellular response to electrical stimulus
.response to ammonium ion
.nucleobase-containing small molecule metabolic process
  + 9 more...
.phosphate ion binding
.GTP binding
.adenylosuccinate synthase activity
.magnesium ion binding
.extracellular exosome
.plasma membrane
.cytosol
.cytoplasm
4 EBI-8463848,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
5 EBI-8463848,EBI-5658292 ZBTB44  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
6 EBI-8463848,EBI-715531 RBM4B  
  .entrainment of circadian clock by photoperiod
.circadian regulation of gene expression
.positive regulation of gene expression
  + 4 more...
.poly(A) RNA binding
.zinc ion binding
.nucleotide binding
.nucleolus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain2
embryonic tissue9
eye4
heart268
intestine4
larynx85
liver4
lung20
mammary gland19
mouth15
muscle141
nerve64
prostate15
thyroid21
Health State
TissuesTPM*
normal19
head and neck tumor7
Developmental Stage
TissuesTPM*
adult10
fetus41
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex1.1
colon1.5
duodenum1.6
esophagus7.7
heart muscle114.1
prostate7.8
small intestine2.8
Tissues
TissuesExpression level
adrenal glandLow
cerebellumLow
cerebral cortexLow
colonLow
duodenumLow
gallbladderLow
heart muscleMedium
kidneyLow
lungMedium
nasopharynxLow
parathyroid glandLow
skeletal muscleMedium
stomach 1Low
testisLow
thyroid glandLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606846, gene) Set and mynd domain-containing protein 1; SMYD1OMIM


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