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> Protein (NX_Q8NBP7)
Protein (NX_Q8NBP7)
Protein
Gene SymbolPCSK9 to neXtProt (NX_Q8NBP7)
DescriptionProprotein convertase subtilisin/kexin type 9
Chromosome1
Location1p32.3 (55505221 ~ 55530525) to Ensembl
Sequene Features : Isoforms 2, Variants 142, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of sodium ion transmembrane transporter activity
.negative regulation of receptor activity
.positive regulation of neuron apoptotic process
  + 22 more...
.very-low-density lipoprotein particle receptor binding
.low-density lipoprotein particle receptor binding
.poly(A) RNA binding
  + 8 more...
.PCSK9-AnxA2 complex
.PCSK9-LDLR complex
.perinuclear region of cytoplasm
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 142 15
2014-09-19protein level
2 120 15
2014-05-27protein level
2 119 15
2014-02-25protein level
2 119 15
2013-12-09protein level
2 98 15
2013-11-01protein level
2 93 15
2013-09-12protein level
2 93 15
2013-08-17protein level
2 93 15
2013-07-15protein level
2 77 15
2013-06-11protein level
2 77 15
2013-02-12protein level
2 63 16
2012-12-20protein level
2 66 16
2012-10-30protein level
2 67 16
2012-10-07protein level
2 67 15
2012-08-24protein level
2 66 5
2012-07-28protein level
2 64 5
2012-06-08protein level
2 68 5
2012-05-07protein level
2 61 5
2012-04-10protein level
2 60 5
2012-01-13protein level
2 55 5
2011-12-20protein level
2 55 5
2011-11-11protein level
2 55 5
2011-08-23protein level
2 55 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NBP7-1
23 6 0 74238.9129
NX_Q8NBP7-2
4 6 0 20813.7082
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7539251,EBI-988319 LDLR  
  .regulation of cholesterol homeostasis
.cholesterol import
.small molecule metabolic process
  + 16 more...
.clathrin heavy chain binding
.very-low-density lipoprotein particle receptor activity
.low-density lipoprotein particle binding
  + 3 more...
.apical part of cell
.receptor complex
.low-density lipoprotein particle
  + 13 more...
2 EBI-7539251,EBI-352622 ANXA2  
  .positive regulation of receptor activity
.negative regulation of receptor binding
.protein targeting to plasma membrane
  + 15 more...
.calcium-dependent protein binding
.poly(A) RNA binding
.S100 protein binding
  + 4 more...
.PCSK9-AnxA2 complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 22 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bone13
brain26
cervix144
connective tissue6
embryonic tissue14
intestine25
liver29
mammary gland13
mouth377
ovary19
pancreas9
salivary gland49
skin4
stomach10
testis50
uterus8
Health State
TissuesTPM*
normal13
cervical tumor57
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor42
germ cell tumor83
head and neck tumor186
leukemia21
liver tumor31
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult20
blastocyst48
neonate32
fetus35
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
colon3.6
duodenum2.7
liver6.6
lung8.4
pancreas1.1
small intestine1.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#603776, phenotype) Hypercholesterolemia, autosomal dominant, 3; HCHOLA3OMIM
2(*607786, gene) Proprotein convertase, subtilisin/kexin-type, 9; PCSK9OMIM


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