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> Protein (NX_Q8NBZ0)
Protein (NX_Q8NBZ0)
Protein
Gene SymbolINO80E to neXtProt (NX_Q8NBZ0)
DescriptionINO80 complex subunit E
Chromosome16
Location16p11.2 (30006615 ~ 30017114) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 0
2014-09-19protein level
1 18 0
2014-05-27protein level
1 18 0
2014-02-25protein level
1 18 0
2013-12-09protein level
1 15 0
2013-11-01protein level
1 14 0
2013-09-12protein level
1 14 0
2013-08-17protein level
1 14 0
2013-07-15protein level
1 7 0
2013-06-11protein level
1 7 0
2013-02-12protein level
1 6 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 6 0
2012-10-07protein level
1 6 0
2012-08-24protein level
1 6 0
2012-07-28protein level
1 6 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 0 0
2011-12-20protein level
1 0 0
2011-11-11protein level
1 0 0
2011-08-23protein level
1 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NBZ0-1
6 4 0 26461.5438
NX_Q8NBZ0-2
1 4 0 15163.6746
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-769401,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-769401,EBI-1049336 TNFAIP8  
  .defense response to Gram-positive bacterium
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
.interleukin-1 beta production
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process .cytoplasm
3 EBI-769401,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
4 EBI-769401,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
5 EBI-769401,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
6 EBI-769401,EBI-744506 FAM124A  
  .N/A .N/A .N/A
7 EBI-769401,EBI-10269566 MORN4  
  .N/A .N/A .N/A
8 EBI-769401,EBI-1051183 UCHL5  
  .regulation of proteasomal protein catabolic process
.forebrain morphogenesis
.midbrain development
  + 10 more...
.proteasome binding
.poly(A) RNA binding
.omega peptidase activity
  + 2 more...
.Ino80 complex
.cytosol
.nucleus
.proteasome complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites351
blood16
bone83
brain33
cervix82
connective tissue20
embryonic tissue84
eye57
heart22
intestine30
kidney18
larynx42
liver34
lung23
lymph90
lymph node22
mammary gland92
mouth15
muscle18
nerve257
ovary19
pancreas65
pituitary gland60
placenta74
prostate15
salivary gland148
skin80
spleen37
stomach52
testis34
thymus37
tonsil117
uterus64
Health State
TissuesTPM*
normal42
adrenal tumor158
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma72
colorectal tumor35
gastrointestinal tumor177
germ cell tumor34
glioma93
head and neck tumor29
kidney tumor14
leukemia10
liver tumor41
lung tumor48
lymphoma138
non-neoplasia20
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS110
prostate cancer38
retinoblastoma43
skin tumor103
soft tissue/muscle tissue tumor31
uterine tumor110
Developmental Stage
TissuesTPM*
adult48
embryoid body57
blastocyst113
fetus28
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.6
adrenal gland35.4
appendix39.5
bone marrow29.4
cerebral cortex21.2
colon29.5
duodenum33.1
esophagus30
gallbladder34.7
heart muscle25.2
kidney26.8
liver13.4
lung39.4
lymph node44.6
ovary41.9
pancreas15.2
placenta25.3
prostate33.3
salivary gland34.5
skin30.2
small intestine36.8
spleen47.4
stomach35.2
testis46
thyroid gland40.7
urinary bladder37.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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