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> Protein (NX_Q8NCP5)
Protein (NX_Q8NCP5)
Protein
Gene SymbolZBTB44 to neXtProt (NX_Q8NCP5)
DescriptionZinc finger and BTB domain-containing protein 44
Chromosome11
Location11q24.3 (130096572 ~ 130184581) to Ensembl
Sequene Features : Isoforms 4, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 53 4
2014-09-19protein level
4 42 4
2014-05-27protein level
4 42 4
2014-02-25protein level
4 42 4
2013-12-09protein level
4 33 4
2013-11-01protein level
4 33 4
2013-09-12protein level
4 33 4
2013-08-17protein level
4 33 4
2013-07-15protein level
4 16 4
2013-06-11protein level
4 16 4
2013-02-12protein level
4 9 16
2012-12-20protein level
4 8 16
2012-10-30protein level
4 11 16
2012-10-07protein level
4 11 4
2012-08-24protein level
4 7 4
2012-07-28protein level
4 7 4
2012-06-08protein level
4 7 4
2012-05-07protein level
4 7 4
2012-04-10protein level
4 7 4
2012-01-13protein level
4 4 4
2011-12-20protein level
4 4 4
2011-11-11protein level
4 4 4
2011-08-23protein level
4 4 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NCP5-1
3 17 0 63806.9768
NX_Q8NCP5-2
1 17 0 52672.5987
NX_Q8NCP5-3
0 17 0 50301.5409
NX_Q8NCP5-4
1 17 0 51732.1259
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5658292,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
2 EBI-5658292,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
3 EBI-5658292,EBI-357793 PSMA6  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteolysis involved in cellular protein catabolic process
  + 26 more...
.NF-kappaB binding
.purine ribonucleoside triphosphate binding
.threonine-type endopeptidase activity
  + 2 more...
.extracellular exosome
.sarcomere
.myofibril
  + 10 more...
4 EBI-5658292,EBI-744506 FAM124A  
  .N/A .N/A .N/A
5 EBI-5658292,EBI-10264625 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
6 EBI-5658292,EBI-8463848 SMYD1  
  .negative regulation of transcription, DNA-templated
.positive regulation of myoblast differentiation
.skeletal muscle cell differentiation
  + 4 more...
.metal ion binding
.histone-lysine N-methyltransferase activity
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleus
7 EBI-5658292,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
8 EBI-5658292,EBI-741774 POLI  
  .error-prone translesion synthesis
.translesion synthesis
.DNA repair
.DNA replication
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood57
bone13
bone marrow61
brain30
cervix20
connective tissue20
ear931
embryonic tissue46
esophagus49
eye47
heart11
intestine38
kidney80
larynx42
liver34
lung26
lymph45
lymph node233
mammary gland39
mouth30
muscle103
ovary39
pancreas70
parathyroid48
placenta28
prostate47
skin23
spleen18
stomach20
testis85
thymus100
thyroid42
trachea57
uterus43
vascular58
Health State
TissuesTPM*
normal59
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma36
colorectal tumor53
gastrointestinal tumor33
germ cell tumor26
glioma9
head and neck tumor22
kidney tumor14
leukemia52
liver tumor52
lung tumor19
lymphoma27
non-neoplasia62
ovarian tumor26
pancreatic tumor76
primitive neuroectodermal tumor of the CNS7
prostate cancer38
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor66
Developmental Stage
TissuesTPM*
adult39
embryoid body14
blastocyst32
neonate64
fetus86
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10
adrenal gland14.8
appendix13.7
bone marrow11.1
cerebral cortex14.1
colon11.4
duodenum11.2
esophagus13.3
gallbladder13.3
heart muscle11
kidney27.6
liver9.8
lung13.6
lymph node20.6
ovary19.7
pancreas8.5
placenta16.4
prostate13.1
salivary gland11.3
skin13.7
small intestine11
spleen18.2
stomach13.5
testis50.8
thyroid gland19.2
urinary bladder20.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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