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> Protein (NX_Q8ND76)
Protein (NX_Q8ND76)
Protein
Gene SymbolCCNY to neXtProt (NX_Q8ND76)
DescriptionCyclin-Y
Chromosome10
Location10p11.21 (35535953 ~ 35860852) to Ensembl
Sequene Features : Isoforms 3, Variants 30, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of canonical Wnt signaling pathway
.cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .extracellular exosome
.plasma membrane
.nucleus
.cytoplasmic cyclin-dependent protein kinase holoenzyme complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 30 18
2014-09-19protein level
3 23 7
2014-05-27protein level
3 23 10
2014-02-25protein level
3 23 10
2013-12-09protein level
3 16 10
2013-11-01protein level
3 16 9
2013-09-12protein level
3 16 11
2013-08-17protein level
3 16 11
2013-07-15protein level
3 11 11
2013-06-11protein level
3 11 11
2013-02-12protein level
3 4 22
2012-12-20protein level
3 4 22
2012-10-30protein level
3 5 22
2012-10-07protein level
3 5 9
2012-08-24protein level
3 4 9
2012-07-28protein level
3 4 9
2012-06-08protein level
3 14 9
2012-05-07protein level
3 13 9
2012-04-10protein level
3 13 9
2012-01-13protein level
3 12 9
2011-12-20protein level
3 12 9
2011-11-11protein level
3 12 7
2011-08-23protein level
3 12 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8ND76-1
1 13 4 39311.8279
NX_Q8ND76-2
0 13 3 36480.5172
NX_Q8ND76-3
1 10 4 33224.0424
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1049189,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
2 EBI-1049189,EBI-359390 CUL1  
  .intrinsic apoptotic signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 17 more...
.N/A .Parkin-FBXW7-Cul1 ubiquitin ligase complex
.cullin-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites50
bladder100
blood16
bone139
bone marrow20
brain47
cervix20
connective tissue107
ear124
embryonic tissue56
eye4
heart167
intestine73
kidney99
liver9
lung5
lymph22
lymph node167
mammary gland72
mouth45
nerve64
ovary78
pancreas51
parathyroid194
pituitary gland121
placenta14
prostate73
skin85
spleen243
stomach94
testis232
thymus12
thyroid107
tonsil58
uterus73
vascular19
Health State
TissuesTPM*
normal94
adrenal tumor237
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma144
colorectal tumor26
gastrointestinal tumor101
germ cell tumor72
glioma102
head and neck tumor59
kidney tumor58
leukemia21
liver tumor20
lung tumor29
lymphoma27
non-neoplasia10
ovarian tumor65
pancreatic tumor85
primitive neuroectodermal tumor of the CNS31
prostate cancer105
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult1
embryoid body71
blastocyst32
fetus122
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.4
adrenal gland28
appendix35.4
bone marrow36
cerebral cortex51.4
colon33
duodenum32
esophagus46.8
gallbladder48.8
heart muscle53.1
kidney38.4
liver27.3
lung38.3
lymph node39.5
ovary40.3
pancreas21.4
placenta45.8
prostate25.4
salivary gland21.5
skin25.9
small intestine35.6
spleen34.4
stomach33
testis194.3
thyroid gland61.6
urinary bladder56.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverHigh
lungLow
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612786, gene) Cyclin y; CCNYOMIM


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