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> Protein (NX_Q8ND90)
Protein (NX_Q8ND90)
Protein
Gene SymbolPNMA1 to neXtProt (NX_Q8ND90)
DescriptionParaneoplastic antigen Ma1
Chromosome14
Location14q24.3 (74178494 ~ 74181128) to Ensembl
Sequene Features : Isoforms 1, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 39 5
2014-09-19protein level
1 32 5
2014-05-27protein level
1 32 5
2014-02-25protein level
1 32 5
2013-12-09protein level
1 24 5
2013-11-01protein level
1 22 4
2013-09-12protein level
1 22 4
2013-08-17protein level
1 22 4
2013-07-15protein level
1 13 0
2013-06-11protein level
1 13 0
2013-02-12protein level
1 7 0
2012-12-20protein level
1 7 0
2012-10-30protein level
1 10 0
2012-10-07protein level
1 10 0
2012-08-24protein level
1 8 0
2012-07-28protein level
1 8 0
2012-06-08protein level
1 8 0
2012-05-07protein level
1 7 0
2012-04-10protein level
1 7 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8ND90-1
15 0 0 39736.1891
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-302345,EBI-10171518 SHISA3  
  .multicellular organismal development .N/A .integral component of membrane
.endoplasmic reticulum membrane
2 EBI-302345,EBI-5453796 GTPBP10  
  .ribosome biogenesis .poly(A) RNA binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitochondrion
.nucleolus
.chromosome
3 EBI-302345,EBI-10178951 GPR25  
  .G-protein coupled receptor signaling pathway .G-protein coupled receptor activity .integral component of plasma membrane
4 EBI-302345,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
5 EBI-302345,EBI-707554 TXNDC9  
  .cell redox homeostasis .N/A .midbody
.centrosome
.cytoplasm
.nucleus
6 EBI-302345,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
7 EBI-302345,EBI-743231 ASMTL  
  .N/A .O-methyltransferase activity .cytoplasm
8 EBI-302345,EBI-751540 GPANK1  
  .N/A .nucleic acid binding .N/A
9 EBI-302345,EBI-10192902 FAM107A  
  .regulation of cell growth .N/A .neuron projection
.nucleus
10 EBI-302345,EBI-1053651 SNRPB2  
  .gene expression
.RNA splicing
.mRNA processing
  + 2 more...
.snRNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nucleolus
.U2 snRNP
  + 2 more...
11 EBI-302345,EBI-10196859 PNMA6D  
  .N/A .N/A .N/A
12 EBI-302345,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
13 EBI-302345,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
14 EBI-302345,EBI-745290 HOXB9  
  .cell chemotaxis
.canonical Wnt signaling pathway
.embryonic skeletal system development
  + 4 more...
.sequence-specific DNA binding .mitochondrion
.nucleoplasm
15 EBI-302345,EBI-746692 TNNI1  
  .ventricular cardiac muscle tissue morphogenesis
.muscle filament sliding
.regulation of striated muscle contraction
.metal ion binding .troponin complex
.cytosol
16 EBI-302345,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
17 EBI-302345,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
18 EBI-302345,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
19 EBI-302345,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
20 EBI-302345,EBI-10210114 NPBWR2  
  .opioid receptor signaling pathway
.synaptic transmission
.neuropeptide signaling pathway
  + 2 more...
.neuropeptide binding
.neuropeptide receptor activity
.opioid receptor activity
.neuron projection
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
21 EBI-302345,EBI-3905829 CCNG1  
  .cell division
.negative regulation of apoptotic process
.cell growth
  + 6 more...
.N/A .perinuclear region of cytoplasm
.neuronal cell body
.dendrite
.nucleus
22 EBI-302345,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
23 EBI-302345,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
24 EBI-302345,EBI-745846 SCAND1  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
25 EBI-302345,EBI-357430 VBP1  
  .'de novo' posttranslational protein folding
.cellular protein metabolic process
.protein folding
.N/A .intracellular membrane-bounded organelle
.prefoldin complex
.cytoplasm
.nucleus
26 EBI-302345,EBI-10223946 WT1-AS  
  .N/A .N/A .N/A
27 EBI-302345,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
28 EBI-302345,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
29 EBI-302345,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
30 EBI-302345,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
31 EBI-302345,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
32 EBI-302345,EBI-1046141 MRPL23  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.structural constituent of ribosome
.RNA binding
.nucleotide binding
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
.mitochondrion
.nucleolus
33 EBI-302345,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
34 EBI-302345,EBI-744560 WDR25  
  .N/A .N/A .N/A
35 EBI-302345,EBI-748373 ZCCHC12  
  .BMP signaling pathway
.transcription, DNA-templated
.ligand-dependent nuclear receptor transcription coactivator activity
.zinc ion binding
.nucleic acid binding
.nuclear speck
36 EBI-302345,EBI-10255185 SLC25A48  
  .transmembrane transport .N/A .integral component of membrane
.mitochondrial inner membrane
37 EBI-302345,EBI-10256202 RSRC2  
  .N/A .poly(A) RNA binding .N/A
38 EBI-302345,EBI-847814 APTX  
  .polynucleotide 3' dephosphorylation
.nucleic acid phosphodiester bond hydrolysis
.response to hydrogen peroxide
  + 6 more...
.phosphoprotein binding
.protein N-terminus binding
.metal ion binding
  + 7 more...
.cytoplasm
.nucleolus
.nucleoplasm
  + 2 more...
39 EBI-302345,EBI-723524 MRPL10  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 4 more...
.poly(A) RNA binding
.structural constituent of ribosome
.ribonucleoprotein complex
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
  + 2 more...
40 EBI-302345,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
41 EBI-302345,EBI-10189722 RPP25L  
  .N/A .poly(A) RNA binding .nucleus
42 EBI-302345,EBI-2851213 TTC9C  
  .N/A .N/A .N/A
43 EBI-302345,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
44 EBI-302345,EBI-741032 CNNM3  
  .ion transport .N/A .integral component of membrane
.membrane
.plasma membrane
45 EBI-302345,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
46 EBI-302345,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
47 EBI-302345,EBI-81968 PARD3  
  .establishment of epithelial cell polarity
.tight junction assembly
.regulation of cellular localization
  + 18 more...
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.apical part of cell
.axonal growth cone
.protein complex
  + 11 more...
48 EBI-302345,EBI-745021 STAMBPL1  
  .N/A .metal ion binding
.metallopeptidase activity
.membrane
49 EBI-302345,EBI-10286267 MED8  
  .protein ubiquitination
.gene expression
.transcription initiation from RNA polymerase II promoter
.RNA polymerase II transcription cofactor activity .mediator complex
.nucleoplasm
50 EBI-302345,EBI-2350695 C5orf30  
  .cilium morphogenesis
.protein transport
.N/A .ciliary transition zone
.cytoplasm
51 EBI-302345,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
52 EBI-302345,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
53 EBI-302345,EBI-10288943 URB1-AS1  
  .N/A .N/A .N/A
54 EBI-302345,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
55 EBI-302345,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
56 EBI-302345,EBI-2515330 FEM1C  
  .protein ubiquitination .N/A .cytoplasm
57 EBI-302345,EBI-302319 MARK4  
  .positive regulation of programmed cell death
.nervous system development
.organelle organization
  + 3 more...
.tau-protein kinase activity
.ubiquitin binding
.gamma-tubulin binding
  + 3 more...
.neuron projection
.ciliary basal body
.microtubule cytoskeleton
  + 3 more...
58 EBI-302345,EBI-742422 CFAP53  
  .N/A .N/A .cilium
59 EBI-302345,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
60 EBI-302345,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
61 EBI-302345,EBI-2949792 NUDT16L1  
  .N/A .poly(A) RNA binding
.snoRNA binding
.hydrolase activity
.cytoplasm
62 EBI-302345,EBI-6257312 RUSC1  
  .positive regulation of signal transduction
.protein polyubiquitination
.SH3/SH2 adaptor activity
.actin binding
.postsynaptic membrane
.cytoplasmic vesicle
.cell junction
  + 8 more...
63 EBI-302345,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
64 EBI-302345,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
65 EBI-302345,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
66 EBI-302345,EBI-741850 SMIM3  
  .N/A .N/A .integral component of membrane
67 EBI-302345,EBI-715611 INO80B  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin remodeling
  + 2 more...
.metal ion binding .Ino80 complex
.plasma membrane
.cytoplasm
  + 3 more...
68 EBI-302345,EBI-10303490 SEMA4C  
  .semaphorin-plexin signaling pathway
.muscle cell differentiation
.positive regulation of stress-activated MAPK cascade
  + 3 more...
.receptor activity .postsynaptic membrane
.synaptic vesicle membrane
.cell junction
  + 3 more...
69 EBI-302345,EBI-1050793 SLIRP  
  .mitochondrion morphogenesis
.sperm motility
.single fertilization
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.perinuclear region of cytoplasm
.sperm flagellum
.ribonucleoprotein complex
  + 3 more...
70 EBI-302345,EBI-372911 SPATC1L  
  .N/A .N/A .N/A
71 EBI-302345,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
72 EBI-302345,EBI-10305303 RSPH9  
  .axoneme assembly
.cilium movement
.N/A .motile cilium
.axoneme
.cytoskeleton
73 EBI-302345,EBI-723127 SUV39H2  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 10 more...
.histone methyltransferase activity (H3-K9 specific)
.zinc ion binding
.chromatin binding
.transcription regulatory region sequence-specific DNA binding
.nuclear heterochromatin
.nucleoplasm
.chromatin
.chromosome, centromeric region
74 EBI-302345,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
75 EBI-302345,EBI-715389 C8orf33  
  .N/A .N/A .N/A
76 EBI-302345,EBI-749353 METTL17  
  .translation .methyltransferase activity
.copper ion binding
.ribosome
.mitochondrion
.nucleoplasm
.nucleus
77 EBI-302345,EBI-81876 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
78 EBI-302345,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
79 EBI-302345,EBI-10320765 POLL  
  .somatic hypermutation of immunoglobulin genes
.nucleotide-excision repair
.DNA replication
.metal ion binding
.lyase activity
.DNA-directed DNA polymerase activity
.DNA binding
.nucleus
80 EBI-302345,EBI-308511 TSPYL4  
  .nucleosome assembly .N/A .nucleus
81 EBI-302345,EBI-2134033 DCTN4  
  .antigen processing and presentation of exogenous peptide antigen via MHC class II
.nuclear migration
.protein N-terminus binding .dynactin complex
.cytoplasmic dynein complex
.cytosol
  + 3 more...
82 EBI-302345,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
83 EBI-302345,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
84 EBI-302345,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
85 EBI-302345,EBI-714599 PIN4  
  .rRNA processing .poly(A) RNA binding
.peptidyl-prolyl cis-trans isomerase activity
.double-stranded DNA binding
  + 2 more...
.extracellular exosome
.preribosome
.spindle
  + 4 more...
86 EBI-302345,EBI-718719 CARHSP1  
  .regulation of mRNA stability
.intracellular signal transduction
.regulation of transcription, DNA-templated
.phosphatase binding
.mRNA 3'-UTR binding
.DNA binding
.extracellular exosome
.P granule
.cytosol
.cytoplasmic mRNA processing body
87 EBI-302345,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
88 EBI-302345,EBI-6659161 MAB21L2  
  .camera-type eye development
.embryonic body morphogenesis
.positive regulation of cell proliferation
  + 2 more...
.N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone41
bone marrow82
brain83
cervix41
connective tissue13
embryonic tissue79
eye105
heart11
intestine47
kidney23
larynx85
liver19
lung56
mammary gland33
mouth15
ovary29
pancreas107
pharynx49
pituitary gland181
placenta17
prostate79
skin23
stomach31
testis62
thyroid21
trachea38
uterus73
vascular38
Health State
TissuesTPM*
normal64
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma24
colorectal tumor71
gastrointestinal tumor8
germ cell tumor22
glioma46
head and neck tumor22
kidney tumor43
leukemia10
liver tumor31
lung tumor58
non-neoplasia82
ovarian tumor39
pancreatic tumor66
primitive neuroectodermal tumor of the CNS62
prostate cancer38
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor110
Developmental Stage
TissuesTPM*
adult65
embryoid body71
blastocyst32
fetus68
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.4
adrenal gland27.2
appendix18.8
bone marrow5.2
cerebral cortex96.3
colon19.1
duodenum10.8
esophagus20.2
gallbladder24.8
heart muscle16.7
kidney27.4
liver2.7
lung13.8
lymph node15
ovary45
pancreas3.9
placenta17.2
prostate40.5
salivary gland5.1
skin5.8
small intestine12.4
spleen16.2
stomach18.2
testis70.4
thyroid gland18.3
urinary bladder27.4
Tissues
TissuesExpression level
cerebellumMedium
cerebral cortexMedium
epididymisLow
hippocampusMedium
lateral ventricleMedium
nasopharynxLow
spleenMedium
testisMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604010, gene) Paraneoplastic antigen ma1; PNMA1OMIM


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