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> Protein (NX_Q8NDP4)
Protein (NX_Q8NDP4)
Protein
Gene SymbolZNF439 to neXtProt (NX_Q8NDP4)
DescriptionZinc finger protein 439
Chromosome19
Location19p13.2 (11959541 ~ 11994565) to Ensembl
Sequene Features : Isoforms 1, Variants 77, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
1 77 0
2014-09-19transcript level
1 60 0
2014-05-27transcript level
1 60 0
2014-02-25transcript level
1 59 0
2013-12-09transcript level
1 51 0
2013-11-01transcript level
1 48 0
2013-09-12transcript level
1 48 0
2013-08-17transcript level
1 48 0
2013-07-15transcript level
1 32 0
2013-06-11transcript level
1 32 0
2013-02-12transcript level
1 12 0
2012-12-20transcript level
1 13 0
2012-10-30transcript level
1 16 0
2012-10-07transcript level
1 16 0
2012-08-24transcript level
1 15 0
2012-07-28transcript level
1 14 0
2012-06-08transcript level
1 14 0
2012-05-07transcript level
1 12 0
2012-04-10transcript level
1 12 0
2012-01-13transcript level
1 7 0
2011-12-20transcript level
1 7 0
2011-11-11transcript level
1 7 0
2011-08-23transcript level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NDP4-1
10 0 10 58357.2369
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747580,EBI-371669 GMNN  
  .negative regulation of transcription, DNA-templated
.negative regulation of cell cycle
.organ morphogenesis
  + 3 more...
.histone deacetylase binding
.transcription corepressor activity
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-747580,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-747580,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
4 EBI-747580,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
5 EBI-747580,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
6 EBI-747580,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
7 EBI-747580,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
8 EBI-747580,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
9 EBI-747580,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-747580,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
11 EBI-747580,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
12 EBI-747580,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain9
embryonic tissue4
heart33
intestine4
larynx42
lung2
lymph22
lymph node22
muscle9
ovary19
pancreas4
parathyroid48
pituitary gland60
placenta24
prostate5
skin4
spleen37
testis16
thymus25
uterus8
vascular19
Health State
TissuesTPM*
normal10
colorectal tumor8
germ cell tumor18
glioma9
head and neck tumor7
lung tumor9
lymphoma13
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult11
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
adrenal gland2.9
appendix4.3
bone marrow4
cerebral cortex4.2
colon4.2
duodenum1
esophagus2
gallbladder3.2
heart muscle2.8
kidney4.2
lung5
lymph node8.8
ovary6.3
pancreas1.1
placenta4.5
prostate4.3
salivary gland2.4
skin7.6
small intestine2.6
spleen6.3
stomach2.9
testis5
thyroid gland6
urinary bladder6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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