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> Protein (NX_Q8NDV7)
Protein (NX_Q8NDV7)
Protein
Gene SymbolTNRC6A to neXtProt (NX_Q8NDV7)
DescriptionTrinucleotide repeat-containing gene 6A protein
Chromosome16
Location16p12.1 (24741016 ~ 24838953) to Ensembl
Sequene Features : Isoforms 6, Variants 274, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.innate immune response
  + 9 more...
.poly(A) RNA binding
.nucleotide binding
.micro-ribonucleoprotein complex
.cytosol
.nucleoplasm
.cytoplasmic mRNA processing body
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 274 6
2014-09-19protein level
6 210 6
2014-05-27protein level
6 210 6
2014-02-25protein level
6 209 6
2013-12-09protein level
6 164 6
2013-11-01protein level
6 156 6
2013-09-12protein level
6 156 7
2013-08-17protein level
6 156 7
2013-07-15protein level
6 105 7
2013-06-11protein level
6 105 7
2013-02-12protein level
6 50 29
2012-12-20protein level
6 50 29
2012-10-30protein level
6 57 29
2012-10-07protein level
6 57 6
2012-08-24protein level
6 56 6
2012-07-28protein level
6 54 6
2012-06-08protein level
6 12 6
2012-05-07protein level
6 12 6
2012-04-10protein level
6 12 6
2012-01-13protein level
6 12 6
2011-12-20protein level
6 12 6
2011-11-11protein level
6 12 3
2011-08-23protein level
6 12 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NDV7-1
0 82 1 210167.9276
NX_Q8NDV7-2
1 73 1 181941.0031
NX_Q8NDV7-3
1 14 0 36130.9649
NX_Q8NDV7-4
1 5 0 17140.1789
NX_Q8NDV7-5
1 80 1 206235.7724
NX_Q8NDV7-6
0 80 1 205025.479
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2269715,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-2269715,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
3 EBI-2269715,EBI-2513054 PAN3  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of cytoplasmic mRNA processing body assembly
.gene expression
  + 4 more...
.metal ion binding
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.PAN complex
.cytosol
.cytoplasmic mRNA processing body
4 EBI-2269715,EBI-2267883 AGO3  
  .regulation of stem cell proliferation
.phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
  + 13 more...
.pre-miRNA binding
.poly(A) RNA binding
.miRNA binding
  + 2 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.RISC complex
  + 4 more...
5 EBI-2269715,EBI-2269696 AGO4  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.innate immune response
  + 12 more...
.pre-miRNA binding
.miRNA binding
.single-stranded RNA binding
.double-stranded RNA binding
.RISC-loading complex
.micro-ribonucleoprotein complex
.RISC complex
  + 4 more...
6 EBI-2269715,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
7 EBI-2269715,EBI-527363 AGO1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 15 more...
.pre-miRNA binding
.poly(A) RNA binding
.miRNA binding
  + 6 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
blood16
bone55
brain45
cervix20
connective tissue87
ear124
embryonic tissue98
eye38
heart67
intestine56
kidney75
larynx213
liver29
lung59
lymph22
lymph node33
mammary gland59
mouth75
muscle28
nerve64
ovary59
pancreas103
parathyroid97
pharynx24
pituitary gland60
placenta52
prostate73
skin37
spleen37
stomach10
testis45
thymus12
thyroid107
trachea38
uterus30
vascular38
Health State
TissuesTPM*
normal56
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma181
colorectal tumor97
gastrointestinal tumor25
germ cell tumor45
glioma74
head and neck tumor119
kidney tumor58
leukemia10
liver tumor20
lung tumor19
lymphoma13
non-neoplasia51
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult67
embryoid body71
blastocyst113
fetus68
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.2
adrenal gland26.2
appendix17
bone marrow11.9
cerebral cortex14.7
colon13
duodenum13.9
esophagus13
gallbladder18.9
heart muscle14.7
kidney14.6
liver13.7
lung16.7
lymph node22
ovary33.7
pancreas8.7
placenta14.5
prostate17.5
salivary gland15
skin23.2
small intestine15.3
spleen18.8
stomach13.6
testis17.8
thyroid gland16.3
urinary bladder16.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610739, gene) Trinucleotide repeat-containing gene 6a; TNRC6AOMIM


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