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> Protein (NX_Q8NE01)
Protein (NX_Q8NE01)
Protein
Gene SymbolCNNM3 to neXtProt (NX_Q8NE01)
DescriptionMetal transporter CNNM3
Chromosome2
Location2q11.2 (97481982 ~ 97499648) to Ensembl
Sequene Features : Isoforms 3, Variants 59, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ion transport .N/A .integral component of membrane
.membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 59 11
2014-09-19protein level
3 48 11
2014-05-27protein level
3 48 11
2014-02-25protein level
3 48 11
2013-12-09protein level
3 32 11
2013-11-01protein level
3 31 8
2013-09-12protein level
3 31 8
2013-08-17protein level
3 31 8
2013-07-15protein level
3 24 6
2013-06-11protein level
3 24 6
2013-02-12protein level
3 14 11
2012-12-20protein level
3 13 11
2012-10-30protein level
3 17 11
2012-10-07protein level
3 17 4
2012-08-24protein level
3 17 4
2012-07-28protein level
3 18 4
2012-06-08protein level
3 25 4
2012-05-07protein level
3 21 4
2012-04-10protein level
3 21 4
2012-01-13protein level
3 12 4
2011-12-20protein level
3 12 4
2011-11-11protein level
3 12 3
2011-08-23protein level
3 12 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NE01-1
2 32 2 76071.8364
NX_Q8NE01-2
0 32 1 70588.0893
NX_Q8NE01-3
2 31 1 73011.3352
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741032,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
2 EBI-741032,EBI-10196781 KRTAP2-3  
  .N/A .N/A .keratin filament
3 EBI-741032,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
4 EBI-741032,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
5 EBI-741032,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-741032,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
7 EBI-741032,EBI-741101 FHL3  
  .actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.nucleus
.stress fiber
8 EBI-10269984,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
9 EBI-741032,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
10 EBI-10269984,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
11 EBI-741032,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
12 EBI-10269984,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
13 EBI-10269984,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
blood16
bone13
brain18
cervix41
connective tissue13
embryonic tissue37
eye76
intestine25
kidney18
larynx42
liver24
lung29
lymph203
lymph node33
mammary gland39
mouth30
muscle56
ovary39
pancreas74
placenta17
prostate5
skin9
stomach10
testis20
uterus21
Health State
TissuesTPM*
normal27
adrenal tumor158
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma24
colorectal tumor35
gastrointestinal tumor33
germ cell tumor26
glioma37
head and neck tumor22
leukemia21
liver tumor31
lung tumor19
lymphoma124
non-neoplasia31
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult28
embryoid body85
blastocyst16
fetus26
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland10.5
appendix9.9
bone marrow5.1
cerebral cortex11.3
colon10.6
duodenum17
esophagus6.5
gallbladder13.3
heart muscle8.2
kidney11
liver13.2
lung12.8
lymph node11.2
ovary13.7
pancreas15.6
placenta10.9
prostate12.6
salivary gland10.6
skin10.2
small intestine16.7
spleen13.2
stomach14.5
testis16.5
thyroid gland9.9
urinary bladder8.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607804, gene) Cyclin m3; CNNM3OMIM


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