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> Protein (NX_Q8NEB9)
Protein (NX_Q8NEB9)
Protein
Gene SymbolPIK3C3 to neXtProt (NX_Q8NEB9)
DescriptionPhosphatidylinositol 3-kinase catalytic subunit type 3
Chromosome18
Location18q12.3 (39535171 ~ 39667794) to Ensembl
Sequene Features : Isoforms 1, Variants 116, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of protein secretion
.phosphatidylinositol-mediated signaling
.phosphatidylinositol phosphorylation
  + 20 more...
.1-phosphatidylinositol-3-kinase activity
.ATP binding
.protein kinase activity
.phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 116 2
2014-09-19protein level
1 98 2
2014-05-27protein level
1 98 2
2014-02-25protein level
1 98 2
2013-12-09protein level
1 84 2
2013-11-01protein level
1 81 2
2013-09-12protein level
1 81 3
2013-08-17protein level
1 81 3
2013-07-15protein level
1 46 3
2013-06-11protein level
1 46 3
2013-02-12protein level
1 21 11
2012-12-20protein level
1 22 11
2012-10-30protein level
1 24 11
2012-10-07protein level
1 24 11
2012-08-24protein level
1 24 11
2012-07-28protein level
1 24 11
2012-06-08protein level
1 47 11
2012-05-07protein level
1 31 11
2012-04-10protein level
1 31 11
2012-01-13protein level
1 30 11
2011-12-20protein level
1 30 11
2011-11-11protein level
1 30 11
2011-08-23protein level
1 30 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NEB9-1
42 0 0 101484.4992
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1056470,EBI-949378 BECN1  
  .positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
2 EBI-1056470,EBI-2952709 KIAA0226  
  .negative regulation of endocytosis
.negative regulation of autophagy
.autophagy
.endocytosis
.N/A .late endosome
.early endosome
.lysosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood16
bone83
bone marrow20
brain23
connective tissue53
embryonic tissue70
eye14
heart33
intestine12
kidney42
larynx42
liver58
lung23
lymph node33
mammary gland13
mouth15
muscle28
ovary9
pancreas14
parathyroid145
pharynx24
pituitary gland60
placenta21
prostate21
skin23
spleen18
stomach10
testis45
thymus62
umbilical cord145
uterus25
vascular19
Health State
TissuesTPM*
normal33
breast (mammary gland) tumor21
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor8
germ cell tumor15
glioma83
head and neck tumor14
kidney tumor43
leukemia21
liver tumor41
lung tumor29
lymphoma27
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult27
embryoid body42
blastocyst113
neonate64
fetus30
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.5
adrenal gland40.2
appendix24.9
bone marrow19.6
cerebral cortex18.2
colon24
duodenum16.5
esophagus22.2
gallbladder25.8
heart muscle19.2
kidney28.3
liver16.8
lung18.8
lymph node27.3
ovary28.8
pancreas8.5
placenta30.4
prostate28.2
salivary gland15.3
skin13.7
small intestine20
spleen23.7
stomach20.2
testis40.6
thyroid gland24.1
urinary bladder31
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusLow
kidneyMedium
lateral ventricleLow
liverHigh
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602609, gene) Phosphatidylinositol 3-kinase, class 3; PIK3C3OMIM


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