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> Protein (NX_Q8NEC5)
Protein (NX_Q8NEC5)
Protein
Gene SymbolCATSPER1 to neXtProt (NX_Q8NEC5)
DescriptionCation channel sperm-associated protein 1
Chromosome11
Location11q13.1 (65784223 ~ 65793988) to Ensembl
Sequene Features : Isoforms 1, Variants 133, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 133 0
2014-09-19protein level
1 108 0
2014-05-27protein level
1 108 0
2014-02-25protein level
1 108 0
2013-12-09protein level
1 80 0
2013-11-01protein level
1 78 0
2013-09-12protein level
1 78 0
2013-08-17protein level
1 78 0
2013-07-15protein level
1 58 0
2013-06-11protein level
1 58 0
2013-02-12protein level
1 29 0
2012-12-20protein level
1 27 0
2012-10-30protein level
1 34 0
2012-10-07protein level
1 34 0
2012-08-24protein level
1 28 0
2012-07-28protein level
1 28 0
2012-06-08protein level
1 29 0
2012-05-07protein level
1 29 0
2012-04-10protein level
1 29 0
2012-01-13protein level
1 16 0
2011-12-20protein level
1 16 0
2011-11-11protein level
1 16 0
2011-08-23protein level
1 16 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NEC5-1
30 0 0 90034.466
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744545,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-744545,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
3 EBI-744545,EBI-10189029 SCRG1  
  .nervous system development .N/A .extracellular space
4 EBI-744545,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
5 EBI-744545,EBI-712648 AGR2  
  .mucus secretion
.lung goblet cell differentiation
.dystroglycan binding .endoplasmic reticulum
.mitochondrion
.extracellular region
6 EBI-744545,EBI-1171525 APOA2  
  .negative regulation of cholesterol transporter activity
.negative regulation of cholesterol import
.negative regulation of lipase activity
  + 39 more...
.high-density lipoprotein particle receptor binding
.phosphatidylcholine-sterol O-acyltransferase activator activity
.lipase inhibitor activity
  + 10 more...
.blood microparticle
.extracellular exosome
.chylomicron
  + 7 more...
7 EBI-744545,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
8 EBI-744545,EBI-489887 EMD  
  .cellular response to growth factor stimulus
.regulation of canonical Wnt signaling pathway
.negative regulation of fibroblast proliferation
  + 8 more...
.beta-tubulin binding
.actin binding
.nuclear membrane
.integral component of membrane
.membrane
  + 5 more...
9 EBI-744545,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
10 EBI-744545,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
11 EBI-744545,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
12 EBI-744545,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
13 EBI-744545,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
14 EBI-744545,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
15 EBI-744545,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
16 EBI-744545,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
17 EBI-744545,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
18 EBI-744545,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
19 EBI-744545,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
20 EBI-744545,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
21 EBI-744545,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
22 EBI-744545,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
23 EBI-744545,EBI-10302547 KRTAP4-7  
  .hair cycle
.aging
.N/A .keratin filament
24 EBI-744545,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
25 EBI-744545,EBI-750734 PLSCR3  
  .cellular response to lipopolysaccharide
.cholesterol homeostasis
.glucose homeostasis
  + 2 more...
.calcium-dependent protein binding
.phospholipid scramblase activity
.calcium ion binding
.mitochondrial membrane
.integral component of membrane
.plasma membrane
26 EBI-744545,EBI-1220829 CACNA1I  
  .membrane depolarization during action potential
.calcium ion import
.sleep
  + 4 more...
.low voltage-gated calcium channel activity
.voltage-gated calcium channel activity
.voltage-gated calcium channel complex
.plasma membrane
27 EBI-744545,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
lung5
testis147
Health State
TissuesTPM*
normal2
chondrosarcoma12
lung tumor19
Developmental Stage
TissuesTPM*
adult1
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1
bone marrow1.3
lung1.4
testis12.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*606389, gene) Cation channel, sperm-associated, 1; CATSPER1OMIM
2(#612997, phenotype) Spermatogenic failure 7; SPGF7OMIM


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