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> Protein (NX_Q8NEF3)
Protein (NX_Q8NEF3)
Protein
Gene SymbolCCDC112 to neXtProt (NX_Q8NEF3)
DescriptionCoiled-coil domain-containing protein 112
Chromosome5
Location5q22.3 (114602885 ~ 114632528) to Ensembl
Sequene Features : Isoforms 2, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 58 1
2014-09-19protein level
2 54 1
2014-05-27protein level
2 54 1
2014-02-25protein level
2 55 1
2013-12-09protein level
2 46 1
2013-11-01protein level
2 43 1
2013-09-12protein level
2 43 1
2013-08-17protein level
2 43 1
2013-07-15protein level
2 26 0
2013-06-11protein level
2 26 0
2013-02-12protein level
2 15 0
2012-12-20protein level
2 15 0
2012-10-30protein level
2 18 0
2012-10-07protein level
2 18 0
2012-08-24transcript level
2 15 0
2012-07-28transcript level
2 15 0
2012-06-08transcript level
2 15 0
2012-05-07transcript level
2 15 0
2012-04-10transcript level
2 15 0
2012-01-13transcript level
2 8 0
2011-12-20transcript level
2 8 0
2011-11-11transcript level
2 8 0
2011-08-23transcript level
2 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NEF3-1
0 16 0 53532.1436
NX_Q8NEF3-2
2 16 0 61882.4477
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745040,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-745040,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
3 EBI-745040,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-745040,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain14
connective tissue93
embryonic tissue14
eye14
intestine21
kidney9
liver14
lung11
mouth196
nerve64
pancreas14
parathyroid48
pituitary gland60
skin4
testis36
uterus4
Health State
TissuesTPM*
normal14
chondrosarcoma12
colorectal tumor35
germ cell tumor3
kidney tumor14
leukemia10
liver tumor10
lung tumor9
non-neoplasia41
skin tumor7
soft tissue/muscle tissue tumor103
uterine tumor11
Developmental Stage
TissuesTPM*
adult14
blastocyst16
fetus19
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland4.7
appendix6.8
bone marrow4.7
cerebral cortex9.2
colon10.2
duodenum7
esophagus4.9
gallbladder4
heart muscle4.9
kidney2.9
lung6
lymph node4.8
ovary2.4
pancreas4.9
placenta2.5
prostate8.3
salivary gland4.8
skin4.1
small intestine6.5
spleen5.8
stomach6.7
testis39.3
thyroid gland4.3
urinary bladder5.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverMedium
lungLow
lymph nodeLow
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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