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> Protein (NX_Q8NEM2)
Protein (NX_Q8NEM2)
Protein
Gene SymbolSHCBP1 to neXtProt (NX_Q8NEM2)
DescriptionSHC SH2 domain-binding protein 1
Chromosome16
Location16q11.2 (46614466 ~ 46655538) to Ensembl
Sequene Features : Isoforms 1, Variants 67, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of neural precursor cell proliferation
.fibroblast growth factor receptor signaling pathway
.N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 67 13
2014-09-19protein level
1 54 13
2014-05-27protein level
1 54 13
2014-02-25protein level
1 54 13
2013-12-09protein level
1 41 13
2013-11-01protein level
1 39 13
2013-09-12protein level
1 39 13
2013-08-17protein level
1 39 13
2013-07-15protein level
1 27 9
2013-06-11protein level
1 27 9
2013-02-12protein level
1 12 8
2012-12-20protein level
1 12 8
2012-10-30protein level
1 14 8
2012-10-07protein level
1 14 8
2012-08-24protein level
1 10 8
2012-07-28protein level
1 10 8
2012-06-08protein level
1 15 8
2012-05-07protein level
1 15 8
2012-04-10protein level
1 15 8
2012-01-13protein level
1 13 8
2011-12-20protein level
1 13 8
2011-11-11protein level
1 13 6
2011-08-23protein level
1 13 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NEM2-1
35 0 0 75641.975
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744700,EBI-706216 PRKCB  
  .cellular response to carbohydrate stimulus
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of B cell receptor signaling pathway
  + 24 more...
.androgen receptor binding
.histone binding
.histone kinase activity (H3-T6 specific)
  + 8 more...
.extracellular exosome
.membrane
.plasma membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone27
bone marrow20
brain10
cervix41
connective tissue33
ear248
embryonic tissue56
esophagus49
intestine4
kidney37
liver24
lung14
lymph node33
mammary gland6
muscle18
ovary9
placenta10
prostate26
skin28
testis16
thymus125
trachea19
uterus12
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma36
esophageal tumor57
germ cell tumor22
glioma27
leukemia31
liver tumor31
lung tumor29
non-neoplasia10
ovarian tumor13
primitive neuroectodermal tumor of the CNS55
prostate cancer48
uterine tumor33
Developmental Stage
TissuesTPM*
adult12
embryoid body71
blastocyst65
neonate128
fetus19
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix8.7
bone marrow22.9
colon2.7
duodenum2.3
esophagus2.3
gallbladder1.1
kidney2.3
lung1
lymph node14.8
placenta4
skin4.2
small intestine1.6
spleen3.1
stomach1.6
testis7.5
urinary bladder3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611027, gene) Shc sh2 domain-binding protein 1; SHCBP1OMIM


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