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> Protein (NX_Q8NEU8)
Protein (NX_Q8NEU8)
Protein
Gene SymbolAPPL2 to neXtProt (NX_Q8NEU8)
DescriptionDCC-interacting protein 13-beta
Chromosome12
Location12q23.3 (105567074 ~ 105630016) to Ensembl
Sequene Features : Isoforms 3, Variants 98, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell proliferation
.signal transduction
.cell cycle
.N/A .extracellular exosome
.early endosome membrane
.endosome membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 98 2
2014-09-19protein level
3 82 2
2014-05-27protein level
3 82 2
2014-02-25protein level
3 81 2
2013-12-09protein level
3 58 2
2013-11-01protein level
3 55 2
2013-09-12protein level
3 55 2
2013-08-17protein level
3 55 2
2013-07-15protein level
3 37 2
2013-06-11protein level
3 37 2
2013-02-12protein level
3 19 0
2012-12-20protein level
3 19 0
2012-10-30protein level
1 26 0
2012-10-07protein level
1 26 0
2012-08-24protein level
1 21 0
2012-07-28protein level
1 21 0
2012-06-08protein level
1 23 0
2012-05-07protein level
1 23 0
2012-04-10protein level
1 23 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NEU8-1
0 33 0 74446.0713
NX_Q8NEU8-2
0 31 0 69701.7052
NX_Q8NEU8-3
1 32 0 75136.4106
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741261,EBI-1054923 RAB5C  
  .plasma membrane to endosome transport
.Rab protein signal transduction
.regulation of endocytosis
  + 2 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.melanosome
  + 6 more...
2 EBI-741261,EBI-520375 CRADD  
  .positive regulation of apoptotic signaling pathway
.cellular response to mechanical stimulus
.extrinsic apoptotic signaling pathway via death domain receptors
  + 2 more...
.death domain binding
.protein binding, bridging
.protease binding
.cytoplasm
.nucleus
3 EBI-741261,EBI-723127 SUV39H2  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 10 more...
.histone methyltransferase activity (H3-K9 specific)
.zinc ion binding
.chromatin binding
.transcription regulatory region sequence-specific DNA binding
.nuclear heterochromatin
.nucleoplasm
.chromatin
.chromosome, centromeric region
4 EBI-741261,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
5 EBI-741261,EBI-399456 RAB22A  
  .regulation of vesicle size
.Rab protein signal transduction
.metabolic process
  + 3 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.phagocytic vesicle
.phagocytic vesicle membrane
  + 5 more...
6 EBI-741261,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood49
bone97
brain31
connective tissue53
ear124
embryonic tissue46
esophagus49
eye38
heart78
intestine86
kidney52
larynx85
liver29
lung32
lymph node55
mammary gland59
mouth30
muscle18
pancreas18
parathyroid145
pituitary gland121
placenta35
prostate36
skin42
spleen18
stomach31
testis73
thymus25
thyroid42
trachea19
uterus56
vascular38
Health State
TissuesTPM*
normal46
breast (mammary gland) tumor10
chondrosarcoma96
colorectal tumor115
esophageal tumor57
gastrointestinal tumor25
germ cell tumor68
glioma9
head and neck tumor29
leukemia52
liver tumor41
lung tumor9
non-neoplasia51
pancreatic tumor9
prostate cancer38
skin tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult58
embryoid body57
blastocyst81
neonate64
fetus53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.6
adrenal gland22.8
appendix19.8
bone marrow22.9
cerebral cortex24.3
colon56.2
duodenum37.1
esophagus18
gallbladder34.6
heart muscle13.1
kidney20.8
liver8
lung19.1
lymph node21.9
ovary31.1
pancreas10.7
placenta21.7
prostate38.2
salivary gland10.9
skin59.9
small intestine53.5
spleen17.8
stomach30.2
testis42.4
thyroid gland16
urinary bladder20
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungHigh
lymph nodeLow
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineHigh
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606231, gene) Adaptor protein, phosphotyrosine interaction, ph domain, and leucineOMIM


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