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> Protein (NX_Q8NF50)
Protein (NX_Q8NF50)
Protein
Gene SymbolDOCK8 to neXtProt (NX_Q8NF50)
DescriptionDedicator of cytokinesis protein 8
Chromosome9
Location9p24.3 (214854 ~ 465259) to Ensembl
Sequene Features : Isoforms 4, Variants 272, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 272 6
2014-09-19protein level
4 217 6
2014-05-27protein level
4 217 6
2014-02-25protein level
4 213 6
2013-12-09protein level
4 176 6
2013-11-01protein level
4 168 3
2013-09-12protein level
4 168 3
2013-08-17protein level
4 168 3
2013-07-15protein level
4 104 3
2013-06-11protein level
4 104 3
2013-02-12protein level
3 64 3
2012-12-20protein level
3 75 3
2012-10-30protein level
3 76 3
2012-10-07protein level
3 76 1
2012-08-24protein level
3 76 1
2012-07-28protein level
3 76 1
2012-06-08protein level
3 85 1
2012-05-07protein level
3 74 1
2012-04-10protein level
3 74 1
2012-01-13protein level
3 34 1
2011-12-20protein level
3 34 1
2011-11-11protein level
3 34 1
2011-08-23protein level
3 34 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NF50-1
0 92 2 238376.6906
NX_Q8NF50-2
0 91 2 235035.166
NX_Q8NF50-3
0 90 2 230672.7345
NX_Q8NF50-4
0 89 2 227331.2099
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10174653,EBI-2692789 CHMP2A  
  .negative regulation of centriole elongation
.positive regulation of exosomal secretion
.positive regulation of viral release from host cell
  + 20 more...
.phosphatidylcholine binding
.protein domain specific binding
.extracellular exosome
.late endosome membrane
.membrane coat
  + 2 more...
2 EBI-10174653,EBI-719843 HBZ  
  .erythrocyte maturation
.negative regulation of transcription from RNA polymerase II promoter
.heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.extracellular exosome
.hemoglobin complex
3 EBI-10174653,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
4 EBI-10174653,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
5 EBI-10174653,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
6 EBI-2548605,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-10174653,EBI-744506 FAM124A  
  .N/A .N/A .N/A
8 EBI-10174653,EBI-394659 MED30  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 4 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.nucleoplasm
.nucleus
9 EBI-10174653,EBI-8795942 LRCH3  
  .N/A .N/A .cytoplasm
.extracellular region
10 EBI-2548605,EBI-447677 MYD88  
  .cellular response to mechanical stimulus
.3'-UTR-mediated mRNA stabilization
.response to interleukin-1
  + 22 more...
.TIR domain binding
.identical protein binding
.death receptor binding
.endosome membrane
.plasma membrane
.cytosol
11 EBI-10174653,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
12 EBI-10174653,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
13 EBI-10174653,EBI-719790 FBXL12  
  .protein ubiquitination
.ubiquitin-dependent protein catabolic process
.N/A .cytoplasm
.ubiquitin ligase complex
14 EBI-10174653,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
15 EBI-10174653,EBI-2797324 LRCH1  
  .N/A .N/A .N/A
16 EBI-10174653,EBI-718719 CARHSP1  
  .regulation of mRNA stability
.intracellular signal transduction
.regulation of transcription, DNA-templated
.phosphatase binding
.mRNA 3'-UTR binding
.DNA binding
.extracellular exosome
.P granule
.cytosol
.cytoplasmic mRNA processing body
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
bladder33
blood98
bone marrow61
brain7
connective tissue6
eye33
intestine21
kidney42
larynx42
lung17
lymph22
lymph node378
mammary gland6
mouth30
muscle9
nerve128
pancreas9
pharynx73
pituitary gland60
placenta42
prostate31
skin61
spleen93
testis45
thymus112
vascular19
Health State
TissuesTPM*
normal42
adrenal tumor79
chondrosarcoma12
colorectal tumor44
germ cell tumor56
glioma18
head and neck tumor22
leukemia105
lung tumor9
lymphoma41
non-neoplasia10
pancreatic tumor9
retinoblastoma64
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult29
fetus19
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.3
adrenal gland9.5
appendix38.3
bone marrow24.9
cerebral cortex3.2
colon7.9
duodenum7.1
esophagus7.2
gallbladder16.8
heart muscle1.6
kidney8
liver3.3
lung16.1
lymph node49.4
ovary2.3
pancreas2.1
placenta16.1
prostate4.3
salivary gland3.7
skin3
small intestine8.1
spleen46.1
stomach11
testis15.9
thyroid gland6.1
urinary bladder22.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#243700, phenotype) Hyper-ige recurrent infection syndrome, autosomal recessiveOMIM
2(*611432, gene) Dedicator of cytokinesis 8; DOCK8OMIM
3(#614113, phenotype) Mental retardation, autosomal dominant 2; MRD2OMIM


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