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> Protein (NX_Q8NF64)
Protein (NX_Q8NF64)
Protein
Gene SymbolZMIZ2 to neXtProt (NX_Q8NF64)
DescriptionZinc finger MIZ domain-containing protein 2
Chromosome7
Location7p13 (44788180 ~ 44809477) to Ensembl
Sequene Features : Isoforms 3, Variants 107, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.ligand-dependent nuclear receptor transcription coactivator activity
.zinc ion binding
.nuclear replication fork
.mitochondrion
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 107 5
2014-09-19protein level
3 72 5
2014-05-27protein level
3 72 5
2014-02-25protein level
3 71 1
2013-12-09protein level
3 51 1
2013-11-01protein level
3 50 1
2013-09-12protein level
3 50 1
2013-08-17protein level
3 50 1
2013-07-15protein level
3 35 1
2013-06-11protein level
3 35 1
2013-02-12protein level
3 16 0
2012-12-20protein level
3 12 0
2012-10-30protein level
3 19 0
2012-10-07protein level
3 19 0
2012-08-24protein level
3 18 0
2012-07-28protein level
3 18 0
2012-06-08protein level
3 18 0
2012-05-07protein level
3 18 0
2012-04-10protein level
3 18 0
2012-01-13protein level
3 14 0
2011-12-20protein level
3 14 0
2011-11-11protein level
3 14 0
2011-08-23protein level
3 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NF64-1
1 20 5 96475.3877
NX_Q8NF64-2
0 21 5 93921.2585
NX_Q8NF64-3
1 20 5 91053.9412
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10182121,EBI-954338 SCAMP1  
  .protein transport
.endocytosis
.post-Golgi vesicle-mediated transport
.exocytosis
.N/A .recycling endosome membrane
.zymogen granule membrane
.synaptic vesicle membrane
  + 3 more...
2 EBI-745786,EBI-2654687 CRCP  
  .defense response to virus
.innate immune response
.positive regulation of type I interferon production
  + 6 more...
.DNA-directed RNA polymerase activity
.calcitonin gene-related peptide receptor activity
.nucleotide binding
.DNA polymerase III complex
.plasma membrane
.cytosol
  + 3 more...
3 EBI-10182121,EBI-743573 TRAPPC6A  
  .vesicle-mediated transport .N/A .Golgi apparatus
.endoplasmic reticulum
4 EBI-10182121,EBI-10208650 NBL1  
  .negative regulation of monocyte chemotaxis
.neuron projection morphogenesis
.determination of dorsal identity
  + 5 more...
.protein homodimerization activity
.BMP binding
.morphogen activity
.extracellular space
5 EBI-10182121,EBI-10216195 SELV  
  .cell redox homeostasis .selenium binding .N/A
6 EBI-745786,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
7 EBI-10182121,EBI-2210673 SSX2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
8 EBI-10182121,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
9 EBI-10182121,EBI-707573 ASB13  
  .intracellular signal transduction
.protein ubiquitination
.N/A .N/A
10 EBI-10182121,EBI-5663129 INTS4  
  .snRNA processing .N/A .integrator complex
11 EBI-10182121,EBI-744298 C2orf88  
  .N/A .N/A .plasma membrane
12 EBI-10182121,EBI-746180 SALL2  
  .neural tube development
.transcription, DNA-templated
.eye development
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.NuRD complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites175
blood40
bone55
bone marrow20
brain82
cervix61
connective tissue20
ear62
embryonic tissue61
esophagus99
eye67
heart11
kidney14
liver14
lung5
mammary gland13
ovary29
pancreas18
prostate5
spleen37
stomach10
testis4
uterus30
Health State
TissuesTPM*
normal50
adrenal tumor158
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma60
colorectal tumor115
esophageal tumor115
gastrointestinal tumor75
germ cell tumor37
glioma158
head and neck tumor37
kidney tumor29
leukemia74
liver tumor31
lung tumor116
non-neoplasia62
ovarian tumor39
pancreatic tumor104
primitive neuroectodermal tumor of the CNS23
prostate cancer77
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult57
embryoid body114
blastocyst32
fetus41
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.4
adrenal gland24.9
appendix50.3
bone marrow26.4
cerebral cortex33.4
colon23
duodenum37.1
esophagus23
gallbladder29.1
heart muscle18.9
kidney24.9
liver9.4
lung40.7
lymph node52
ovary25.5
pancreas23
placenta20.8
prostate33.2
salivary gland42.3
skin58.5
small intestine35
spleen66
stomach43.7
testis40.3
thyroid gland41.1
urinary bladder26.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611196, gene) Zing finger miz-domain containing 2; ZMIZ2OMIM


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