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> Protein (NX_Q8NFZ0)
Protein (NX_Q8NFZ0)
Protein
Gene SymbolFBXO18 to neXtProt (NX_Q8NFZ0)
DescriptionF-box only protein 18
Chromosome10
Location10p15.1 (5931535 ~ 5979556) to Ensembl
Sequene Features : Isoforms 2, Variants 115, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.response to intra-S DNA damage checkpoint signaling
.positive regulation of protein phosphorylation
.DNA catabolic process, endonucleolytic
.ATP binding
.ATP-dependent DNA helicase activity
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 115 1
2014-09-19protein level
2 89 1
2014-05-27protein level
2 89 1
2014-02-25protein level
2 89 1
2013-12-09protein level
2 75 1
2013-11-01protein level
2 73 1
2013-09-12protein level
2 73 1
2013-08-17protein level
2 73 1
2013-07-15protein level
2 46 0
2013-06-11protein level
2 46 0
2013-02-12protein level
2 22 0
2012-12-20protein level
2 21 0
2012-10-30protein level
2 26 0
2012-10-07protein level
2 26 0
2012-08-24protein level
2 24 0
2012-07-28protein level
2 24 0
2012-06-08protein level
2 29 0
2012-05-07protein level
2 20 0
2012-04-10protein level
2 20 0
2012-01-13protein level
2 13 0
2011-12-20protein level
2 13 0
2011-11-11protein level
2 13 0
2011-08-23protein level
2 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NFZ0-1
0 54 0 117610.9472
NX_Q8NFZ0-2
2 54 0 123295.4903
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-724767,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland121
ascites50
blood65
bone83
bone marrow20
brain51
cervix103
connective tissue73
embryonic tissue32
esophagus99
eye124
heart111
intestine99
kidney52
larynx42
liver48
lung95
lymph22
lymph node66
mammary gland59
mouth181
muscle37
nerve128
ovary59
pancreas182
pharynx24
pituitary gland121
placenta35
prostate58
salivary gland197
skin99
spleen56
stomach20
testis128
thymus150
thyroid150
trachea77
uterus90
Health State
TissuesTPM*
normal55
adrenal tumor158
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma96
colorectal tumor115
esophageal tumor115
gastrointestinal tumor33
germ cell tumor41
glioma93
head and neck tumor186
kidney tumor101
leukemia116
liver tumor31
lung tumor48
lymphoma27
non-neoplasia82
ovarian tumor52
pancreatic tumor171
primitive neuroectodermal tumor of the CNS39
prostate cancer57
retinoblastoma129
skin tumor103
soft tissue/muscle tissue tumor71
uterine tumor77
Developmental Stage
TissuesTPM*
adult82
embryoid body57
blastocyst32
neonate32
fetus53
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.1
adrenal gland35.6
appendix29
bone marrow21.3
cerebral cortex17.2
colon29.4
duodenum27.3
esophagus25.2
gallbladder29.4
heart muscle35.6
kidney24.6
liver13.2
lung28
lymph node32.4
ovary29.2
pancreas11.1
placenta27.2
prostate28.6
salivary gland21.3
skin39.6
small intestine27.4
spleen36.7
stomach24.8
testis34.2
thyroid gland23.3
urinary bladder33
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607222, gene) F-box only protein 18; FBXO18OMIM


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