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> Protein (NX_Q8NI08)
Protein (NX_Q8NI08)
Protein
Gene SymbolNCOA7 to neXtProt (NX_Q8NI08)
DescriptionNuclear receptor coactivator 7
Chromosome6
Location6q22.32 (126102307 ~ 126252266) to Ensembl
Sequene Features : Isoforms 7, Variants 100, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.nuclear hormone receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
.nucleus
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 100 16
2014-09-19protein level
7 81 16
2014-05-27protein level
7 81 16
2014-02-25protein level
7 81 16
2013-12-09protein level
7 60 16
2013-11-01protein level
7 59 15
2013-09-12protein level
7 59 14
2013-08-17protein level
7 59 14
2013-07-15protein level
7 41 14
2013-06-11protein level
7 41 14
2013-02-12protein level
7 20 56
2012-12-20protein level
6 21 47
2012-10-30protein level
6 27 47
2012-10-07protein level
6 27 13
2012-08-24protein level
6 25 13
2012-07-28protein level
6 25 13
2012-06-08protein level
6 14 13
2012-05-07protein level
6 14 13
2012-04-10protein level
6 14 13
2012-01-13protein level
6 14 13
2011-12-20protein level
6 14 13
2011-11-11protein level
6 14 10
2011-08-23protein level
6 14 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8NI08-1
1 45 0 106094.9215
NX_Q8NI08-2
0 46 0 104781.2813
NX_Q8NI08-3
0 11 0 33123.7751
NX_Q8NI08-4
1 9 0 28228.4354
NX_Q8NI08-5
2 9 0 25254.4869
NX_Q8NI08-6
1 3 0 12181.2226
NX_Q8NI08-7
0 42 0 92413.9021
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-80799,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-80799,EBI-80809 ARNT  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.positive regulation of hormone biosynthetic process
  + 14 more...
.protein heterodimerization activity
.enhancer binding
.aryl hydrocarbon receptor binding
  + 4 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-80799,EBI-80780 AHR  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
.positive regulation of transcription, DNA-templated
  + 16 more...
.E-box binding
.Hsp90 protein binding
.protein dimerization activity
  + 10 more...
.nuclear aryl hydrocarbon receptor complex
.cytosolic aryl hydrocarbon receptor complex
.cytoplasm
  + 3 more...
4 EBI-80799,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder100
blood32
bone55
bone marrow225
brain39
cervix20
connective tissue46
embryonic tissue9
esophagus49
eye33
intestine64
kidney99
liver14
lung62
lymph node55
mammary gland19
mouth30
muscle47
nerve64
ovary39
pancreas32
pharynx122
pituitary gland181
placenta24
prostate15
skin9
spleen18
stomach41
testis6
thymus75
thyroid64
trachea212
uterus47
Health State
TissuesTPM*
normal42
adrenal tumor79
cervical tumor28
chondrosarcoma60
colorectal tumor62
esophageal tumor57
gastrointestinal tumor50
germ cell tumor45
head and neck tumor29
kidney tumor14
leukemia52
lung tumor19
non-neoplasia72
ovarian tumor39
primitive neuroectodermal tumor of the CNS23
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor88
Developmental Stage
TissuesTPM*
adult38
embryoid body14
blastocyst16
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue42.4
adrenal gland60.7
appendix46.3
bone marrow26.8
cerebral cortex53
colon34.2
duodenum29.5
esophagus31.8
gallbladder53.7
heart muscle7.4
kidney83.6
liver27.6
lung45.9
lymph node28.3
ovary12.9
pancreas10.9
placenta11
prostate16.6
salivary gland22.2
skin9.4
small intestine34.6
spleen20.3
stomach30.7
testis9.1
thyroid gland28.1
urinary bladder80.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609752, gene) Nuclear receptor coactivator 7; NCOA7OMIM


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