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> Protein (NX_Q8TAB5)
Protein (NX_Q8TAB5)
Protein
Gene SymbolC1orf216 to neXtProt (NX_Q8TAB5)
DescriptionUPF0500 protein C1orf216
Chromosome1
Location1p34.3 (36179476 ~ 36185073) to Ensembl
Sequene Features : Isoforms 1, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 24 0
2014-09-19protein level
1 21 0
2014-05-27protein level
1 21 0
2014-02-25protein level
1 21 0
2013-12-09protein level
1 18 0
2013-11-01protein level
1 16 0
2013-09-12protein level
1 16 0
2013-08-17protein level
1 16 0
2013-07-15transcript level
1 11 0
2013-06-11transcript level
1 11 0
2013-02-12transcript level
1 9 0
2012-12-20transcript level
1 8 0
2012-10-30transcript level
1 9 0
2012-10-07transcript level
1 9 0
2012-08-24transcript level
1 7 0
2012-07-28transcript level
1 7 0
2012-06-08transcript level
1 8 0
2012-05-07transcript level
1 8 0
2012-04-10transcript level
1 8 0
2012-01-13transcript level
1 2 0
2011-12-20transcript level
1 2 0
2011-11-11transcript level
1 2 0
2011-08-23transcript level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TAB5-1
12 0 0 24952.1791
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747505,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
2 EBI-747505,EBI-351158 TPM1  
  .cardiac muscle contraction
.ventricular cardiac muscle tissue morphogenesis
.positive regulation of stress fiber assembly
  + 15 more...
.structural constituent of muscle
.cytoskeletal protein binding
.structural constituent of cytoskeleton
.actin binding
.ruffle membrane
.bleb
.filamentous actin
  + 5 more...
3 EBI-747505,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-747505,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
5 EBI-747505,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
6 EBI-747505,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
7 EBI-747505,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
8 EBI-747505,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
9 EBI-747505,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
10 EBI-747505,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
11 EBI-747505,EBI-3891843 AMOT  
  .positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
12 EBI-747505,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
13 EBI-747505,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
14 EBI-747505,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
15 EBI-747505,EBI-750686 LINC00521  
  .N/A .N/A .N/A
16 EBI-747505,EBI-1759414 MYRIP  
  .positive regulation of insulin secretion
.intracellular protein transport
.zinc ion binding .perinuclear region of cytoplasm
.synapse
.melanosome
  + 5 more...
17 EBI-747505,EBI-2362014 NRBF2  
  .gene expression
.transcription initiation from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.N/A .cytoplasm
.nucleoplasm
18 EBI-747505,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
19 EBI-747505,EBI-10173858 CCDC114  
  .outer dynein arm assembly .N/A .outer dynein arm
.cilium
20 EBI-747505,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
21 EBI-747505,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
22 EBI-747505,EBI-447141 GGA1  
  .positive regulation of protein catabolic process
.vesicle-mediated transport
.intracellular protein transport
.N/A .intracellular membrane-bounded organelle
.clathrin adaptor complex
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
blood32
bone27
brain69
cervix41
connective tissue33
embryonic tissue9
esophagus49
eye38
intestine21
kidney14
liver4
lung11
lymph node22
mammary gland26
mouth30
ovary49
pancreas32
placenta28
prostate63
salivary gland98
skin61
spleen37
testis22
thymus25
thyroid42
uterus25
vascular19
Health State
TissuesTPM*
normal40
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma84
colorectal tumor17
esophageal tumor57
gastrointestinal tumor8
germ cell tumor45
glioma46
head and neck tumor37
kidney tumor14
leukemia31
liver tumor10
lung tumor29
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer19
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult35
neonate64
fetus59
infant170
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.8
adrenal gland8.6
appendix5.8
bone marrow2.5
cerebral cortex33.6
colon4.3
duodenum2.7
esophagus4.3
gallbladder7.3
heart muscle6.5
kidney2.2
liver2.6
lung6.5
lymph node6.1
ovary6.6
pancreas1.6
placenta3.1
prostate5.3
salivary gland2.1
skin5.3
small intestine2.5
spleen5.3
stomach2.6
testis8.3
thyroid gland4
urinary bladder6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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