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> Protein (NX_Q8TAD8)
Protein (NX_Q8TAD8)
Protein
Gene SymbolSNIP1 to neXtProt (NX_Q8TAD8)
DescriptionSmad nuclear-interacting protein 1
Chromosome1
Location1p34.3 (38000050 ~ 38019903) to Ensembl
Sequene Features : Isoforms 1, Variants 57, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein targeting to mitochondrion
.production of miRNAs involved in gene silencing by miRNA
.I-kappaB kinase/NF-kappaB signaling
.regulation of transcription, DNA-templated
.poly(A) RNA binding .cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 57 10
2014-09-19protein level
1 48 10
2014-05-27protein level
1 48 10
2014-02-25protein level
1 48 10
2013-12-09protein level
1 42 10
2013-11-01protein level
1 40 10
2013-09-12protein level
1 40 10
2013-08-17protein level
1 40 10
2013-07-15protein level
1 29 9
2013-06-11protein level
1 29 9
2013-02-12protein level
1 17 13
2012-12-20protein level
1 16 13
2012-10-30protein level
1 18 13
2012-10-07protein level
1 18 13
2012-08-24protein level
1 13 13
2012-07-28protein level
1 13 13
2012-06-08protein level
1 16 13
2012-05-07protein level
1 15 13
2012-04-10protein level
1 15 13
2012-01-13protein level
1 9 13
2011-12-20protein level
1 9 13
2011-11-11protein level
1 9 11
2011-08-23protein level
1 9 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TAD8-1
17 0 0 45750.1921
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749336,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
2 EBI-749336,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
3 EBI-749336,EBI-713456 IK  
  .cell-cell signaling
.immune response
.identical protein binding .nucleolus
.nucleoplasm
.extracellular space
4 EBI-749336,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
5 EBI-749336,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood57
bone55
bone marrow41
brain40
cervix41
connective tissue20
embryonic tissue14
eye43
heart11
intestine21
kidney18
liver34
lung38
lymph node44
mammary gland6
mouth30
muscle9
nerve64
pancreas4
pituitary gland121
placenta24
prostate21
skin18
spleen74
testis43
thymus50
thyroid21
trachea38
umbilical cord145
uterus25
vascular38
Health State
TissuesTPM*
normal29
bladder carcinoma56
breast (mammary gland) tumor10
chondrosarcoma48
colorectal tumor35
germ cell tumor91
glioma37
head and neck tumor29
leukemia42
liver tumor20
lymphoma27
non-neoplasia31
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
prostate cancer28
retinoblastoma43
skin tumor7
Developmental Stage
TissuesTPM*
adult30
blastocyst32
neonate96
fetus37
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland4.9
appendix4.6
bone marrow11.3
cerebral cortex3.4
colon4.6
duodenum3.3
esophagus4
gallbladder4.1
heart muscle2.8
kidney3.6
liver4.7
lung4.3
lymph node5.4
ovary5.5
pancreas1.9
placenta3.8
prostate4.9
salivary gland3
skin3.6
small intestine3.1
spleen4.5
stomach4.1
testis7.1
thyroid gland4.4
urinary bladder4.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608241, gene) Smad nuclear interacting protein 1; SNIP1OMIM
2(#614501, phenotype) Psychomotor retardation, epilepsy, and craniofacial dysmorphism;OMIM


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