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> Protein (NX_Q8TAP4)
Protein (NX_Q8TAP4)
Protein
Gene SymbolLMO3 to neXtProt (NX_Q8TAP4)
DescriptionLIM domain only protein 3
Chromosome12
Location12p12.3 (16701307 ~ 16763528) to Ensembl
Sequene Features : Isoforms 4, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of glucocorticoid receptor signaling pathway
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of fat cell differentiation
  + 3 more...
.zinc ion binding .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 22 0
2014-09-19protein level
4 15 0
2014-05-27transcript level
4 15 0
2014-02-25transcript level
4 15 0
2013-12-09transcript level
4 13 0
2013-11-01transcript level
4 13 0
2013-09-12transcript level
4 13 0
2013-08-17transcript level
4 13 0
2013-07-15transcript level
3 6 0
2013-06-11transcript level
3 6 0
2013-02-12transcript level
3 1 0
2012-12-20transcript level
1 1 0
2012-10-30transcript level
1 1 0
2012-10-07transcript level
1 1 0
2012-08-24transcript level
1 0 0
2012-07-28transcript level
1 0 0
2012-06-08transcript level
1 1 0
2012-05-07transcript level
1 4 0
2012-04-10transcript level
1 4 0
2012-01-13transcript level
1 2 0
2011-12-20transcript level
1 2 0
2011-11-11transcript level
1 2 0
2011-08-23transcript level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TAP4-1
0 4 4 16581.9725
NX_Q8TAP4-2
1 3 3 19046.195
NX_Q8TAP4-3
1 3 4 17886.6598
NX_Q8TAP4-4
1 3 4 18424.8863
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742259,EBI-10198587 SP4  
  .regulation of heart contraction
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription coactivator activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.intercellular bridge
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
2 EBI-742259,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
3 EBI-742259,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
4 EBI-742259,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
5 EBI-742259,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
6 EBI-742259,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
7 EBI-742259,EBI-748741 SAMD3  
  .N/A .N/A .N/A
8 EBI-742259,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
9 EBI-742259,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
10 EBI-742259,EBI-3864120 FBLIM1  
  .cell junction assembly
.regulation of integrin activation
.single organismal cell-cell adhesion
.regulation of cell shape
.filamin binding
.zinc ion binding
.cell cortex
.focal adhesion
.cytosol
.stress fiber
11 EBI-742259,EBI-741921 FAM131C  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
brain402
connective tissue20
eye9
intestine4
kidney23
liver4
lung71
mammary gland13
muscle56
nerve64
ovary19
placenta14
prostate5
testis22
thymus37
thyroid236
trachea77
uterus38
Health State
TissuesTPM*
normal130
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor8
germ cell tumor30
glioma74
head and neck tumor74
kidney tumor58
lung tumor9
lymphoma55
non-neoplasia72
ovarian tumor26
uterine tumor33
Developmental Stage
TissuesTPM*
adult29
fetus269
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.6
adrenal gland10.9
appendix3.8
cerebral cortex123.7
colon10.3
duodenum1.8
esophagus3
gallbladder9.6
heart muscle3.8
kidney4.7
lung46
ovary12.1
pancreas30.2
placenta2
prostate13.9
salivary gland3.4
small intestine4.7
thyroid gland45.4
urinary bladder23.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*180386, gene) Lim domain only 3; LMO3OMIM


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