Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q8TAP6)
Protein (NX_Q8TAP6)
Protein
Gene SymbolCEP76 to neXtProt (NX_Q8TAP6)
DescriptionCentrosomal protein of 76 kDa
Chromosome18
Location18p11.21 (12661832 ~ 12702776) to Ensembl
Sequene Features : Isoforms 3, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 50 1
2014-09-19protein level
3 40 1
2014-05-27protein level
3 40 1
2014-02-25protein level
3 40 1
2013-12-09protein level
3 32 1
2013-11-01protein level
3 32 1
2013-09-12protein level
3 32 1
2013-08-17protein level
3 32 1
2013-07-15protein level
3 21 1
2013-06-11protein level
3 21 1
2013-02-12protein level
3 9 2
2012-12-20protein level
3 10 2
2012-10-30protein level
3 11 2
2012-10-07protein level
3 11 1
2012-08-24protein level
3 7 1
2012-07-28protein level
3 7 1
2012-06-08protein level
3 2 1
2012-05-07protein level
3 2 1
2012-04-10protein level
3 2 1
2012-01-13protein level
3 2 1
2011-12-20protein level
3 6 1
2011-11-11protein level
3 6 1
2011-08-23protein level
3 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TAP6-1
4 27 0 74365.4373
NX_Q8TAP6-2
0 27 0 65690.1161
NX_Q8TAP6-3
1 12 0 29650.147
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742887,EBI-720553 ILVBL  
  .N/A .thiamine pyrophosphate binding
.transferase activity
.magnesium ion binding
.integral component of membrane
.membrane
2 EBI-742887,EBI-707554 TXNDC9  
  .cell redox homeostasis .N/A .midbody
.centrosome
.cytoplasm
.nucleus
3 EBI-742887,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
4 EBI-742887,EBI-10185182 AKAP7  
  .positive regulation of delayed rectifier potassium channel activity
.positive regulation of potassium ion transmembrane transport
.cellular response to cAMP
  + 5 more...
.protein kinase A binding .lateral plasma membrane
.apical plasma membrane
.plasma membrane
5 EBI-742887,EBI-1783068 MBD3  
  .ATP-dependent chromatin remodeling
.histone acetylation
.tissue development
  + 5 more...
.methyl-CpG binding
.chromatin binding
.DNA binding
.protein complex
.NuRD complex
.cytoplasm
  + 3 more...
6 EBI-742887,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
7 EBI-742887,EBI-7519711 CRYBA4  
  .camera-type eye development
.visual perception
.structural constituent of eye lens .N/A
8 EBI-742887,EBI-10223330 ZNF85  
  .negative regulation of nucleic acid-templated transcription
.transcription, DNA-templated
.metal ion binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleoplasm
.nucleus
9 EBI-742887,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
10 EBI-742887,EBI-2562000 TOB2  
  .positive regulation of ossification
.negative regulation of osteoclast differentiation
.regulation of gene expression
  + 2 more...
.N/A .cytoplasm
.nucleus
11 EBI-742887,EBI-719994 CCDC92  
  .N/A .N/A .centriole
12 EBI-742887,EBI-7317823 C22orf39  
  .N/A .N/A .N/A
13 EBI-742887,EBI-627102 CIR1  
  .negative regulation of transcription, DNA-templated
.RNA splicing
.mRNA processing
  + 2 more...
.transcription corepressor activity
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding transcription factor activity
.nuclear speck
.microtubule organizing center
.cytoplasm
.nucleus
14 EBI-742887,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
15 EBI-742887,EBI-10264440 DZIP1L  
  .cilium assembly .metal ion binding .ciliary basal body
16 EBI-742887,EBI-10264625 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
17 EBI-742887,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
18 EBI-742887,EBI-10269163 NHLRC2  
  .N/A .N/A .N/A
19 EBI-742887,EBI-8472352 KLHDC4  
  .N/A .N/A .N/A
20 EBI-742887,EBI-2341619 RNF128  
  .negative regulation of cytokine biosynthetic process .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.integral component of membrane
.cytoskeleton
  + 3 more...
21 EBI-742887,EBI-2548425 KIAA1143  
  .N/A .N/A .N/A
22 EBI-742887,EBI-739990 POM121  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.N/A .nuclear membrane
.endoplasmic reticulum membrane
.nuclear pore
.nuclear envelope
23 EBI-742887,EBI-769261 EAF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
24 EBI-742887,EBI-744267 RADIL  
  .substrate adhesion-dependent cell spreading
.multicellular organismal development
.signal transduction
.N/A .microtubule
25 EBI-742887,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
26 EBI-742887,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
27 EBI-742887,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
28 EBI-742887,EBI-1383814 CSNK1G1  
  .peptidyl-serine phosphorylation
.Wnt signaling pathway
.regulation of cell shape
.endocytosis
.ATP binding
.protein serine/threonine kinase activity
.cytoplasm
.nucleus
29 EBI-742887,EBI-2557363 TUFT1  
  .odontogenesis
.bone mineralization
.structural constituent of tooth enamel .cytoplasm
.extracellular region
30 EBI-742887,EBI-10311131 CABP5  
  .signal transduction .calcium ion binding .cytosol
31 EBI-742887,EBI-3396023 PLCB1  
  .positive regulation of CD24 biosynthetic process
.negative regulation of monocyte extravasation
.positive regulation of acrosome reaction
  + 30 more...
.protein homodimerization activity
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
  + 5 more...
.extracellular exosome
.nuclear membrane
.nuclear speck
  + 4 more...
32 EBI-742887,EBI-714918 CUTC  
  .transmembrane transport
.copper ion homeostasis
.protein tetramerization
  + 2 more...
.copper ion binding .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
33 EBI-742887,EBI-10316460 GDAP2  
  .response to retinoic acid .N/A .lysosomal membrane
34 EBI-742887,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
35 EBI-742887,EBI-746180 SALL2  
  .neural tube development
.transcription, DNA-templated
.eye development
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.NuRD complex
36 EBI-742887,EBI-717229 TSSC4  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood40
bone27
bone marrow20
brain13
cervix20
connective tissue6
embryonic tissue23
eye14
heart11
intestine4
kidney14
liver4
lung2
lymph22
lymph node33
mouth166
muscle9
pancreas4
pharynx73
prostate5
salivary gland49
skin18
stomach10
testis73
thymus25
thyroid21
uterus17
vascular38
Health State
TissuesTPM*
normal17
cervical tumor28
chondrosarcoma24
gastrointestinal tumor25
germ cell tumor26
head and neck tumor112
kidney tumor14
leukemia52
liver tumor10
lymphoma13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma64
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult16
embryoid body28
blastocyst32
neonate96
fetus16
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.8
adrenal gland3.5
appendix3.7
bone marrow7.9
cerebral cortex3.4
colon3.8
duodenum2.9
esophagus4.7
gallbladder3.2
heart muscle2.5
kidney2.7
liver3.3
lung2.8
lymph node4.4
ovary4.1
pancreas1.4
placenta3.7
prostate3.2
salivary gland2.1
skin3.6
small intestine3.3
spleen2.9
stomach3
testis22.9
thyroid gland3.3
urinary bladder3.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandLow
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center