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> Protein (NX_Q8TAU3)
Protein (NX_Q8TAU3)
Protein
Gene SymbolZNF417 to neXtProt (NX_Q8TAU3)
DescriptionZinc finger protein 417
Chromosome19
Location19q13.43 (58411664 ~ 58427978) to Ensembl
Sequene Features : Isoforms 2, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 67 0
2014-09-19protein level
1 53 0
2014-05-27transcript level
1 53 0
2014-02-25transcript level
1 53 0
2013-12-09transcript level
1 44 0
2013-11-01transcript level
1 44 0
2013-09-12transcript level
1 44 0
2013-08-17transcript level
1 44 0
2013-07-15transcript level
1 31 0
2013-06-11transcript level
1 31 0
2013-02-12transcript level
1 18 0
2012-12-20transcript level
1 18 0
2012-10-30transcript level
1 14 0
2012-10-07transcript level
1 14 0
2012-08-24transcript level
1 13 0
2012-07-28transcript level
1 13 0
2012-06-08transcript level
1 15 0
2012-05-07transcript level
1 15 0
2012-04-10transcript level
1 15 0
2012-01-13transcript level
1 6 0
2011-12-20transcript level
1 6 0
2011-11-11transcript level
1 6 0
2011-08-23transcript level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TAU3-1
1 5 26 65690.7349
NX_Q8TAU3-2
1 5 20 43183.6703
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740727,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-740727,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
3 EBI-740727,EBI-718488 EFS  
  .intracellular signal transduction
.cell adhesion
.protein domain specific binding .cytoplasm
4 EBI-740727,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
5 EBI-740727,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
6 EBI-740727,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
7 EBI-740727,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
8 EBI-740727,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
9 EBI-740727,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
10 EBI-740727,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
11 EBI-740727,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
12 EBI-740727,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
13 EBI-740727,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
14 EBI-740727,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
15 EBI-740727,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
16 EBI-740727,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
17 EBI-740727,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
18 EBI-740727,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
19 EBI-740727,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
20 EBI-740727,EBI-741101 FHL3  
  .actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.nucleus
.stress fiber
21 EBI-740727,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
22 EBI-740727,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
23 EBI-740727,EBI-747225 RUNDC3A  
  .small GTPase mediated signal transduction .GTPase regulator activity
.guanylate cyclase activator activity
.plasma membrane
.cytosol
24 EBI-740727,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
25 EBI-740727,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
26 EBI-740727,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
27 EBI-740727,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
28 EBI-740727,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
29 EBI-740727,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
30 EBI-740727,EBI-724373 BEND5  
  .N/A .N/A .Golgi apparatus
31 EBI-740727,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
32 EBI-740727,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
33 EBI-740727,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
34 EBI-740727,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
35 EBI-740727,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
36 EBI-740727,EBI-10235384 ZBTB10  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleoplasm
37 EBI-740727,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
38 EBI-740727,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
39 EBI-740727,EBI-741355 LURAP1  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.actomyosin structure organization
.cell migration
.positive regulation of cytokine production
.N/A .actomyosin
.cytoplasm
40 EBI-740727,EBI-4311573 CSRNP1  
  .face morphogenesis
.palate development
.skeletal system morphogenesis
  + 4 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
41 EBI-740727,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
42 EBI-740727,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
43 EBI-740727,EBI-739657 KXD1  
  .vesicle-mediated transport .N/A .BLOC-1 complex
44 EBI-740727,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
45 EBI-740727,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
46 EBI-740727,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
47 EBI-740727,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
48 EBI-740727,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
49 EBI-740727,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
50 EBI-740727,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
51 EBI-740727,EBI-2341518 TRIM36  
  .regulation of cell cycle
.acrosome reaction
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.extracellular exosome
.cytoskeleton
.acrosomal vesicle
52 EBI-740727,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
53 EBI-740727,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
54 EBI-740727,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
55 EBI-740727,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
56 EBI-740727,EBI-719716 NINL  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.calcium ion binding .microtubule
.cytosol
.microtubule organizing center
57 EBI-740727,EBI-2682961 ZBTB1  
  .positive regulation of pro-T cell differentiation
.protein homooligomerization
.thymus development
  + 8 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
.DNA binding
.nuclear body
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone27
brain4
embryonic tissue9
heart11
larynx127
liver4
mammary gland19
placenta10
testis6
thyroid21
trachea19
uterus8
Health State
TissuesTPM*
normal4
breast (mammary gland) tumor32
germ cell tumor3
glioma18
head and neck tumor29
leukemia21
primitive neuroectodermal tumor of the CNS15
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult6
embryoid body14
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland6.2
appendix6.6
bone marrow6.3
cerebral cortex5.2
colon6
duodenum6.1
esophagus3.7
gallbladder4.7
heart muscle3.3
kidney4.8
liver3.6
lung5.4
lymph node6.6
ovary6.7
pancreas2.8
placenta4.8
prostate8
salivary gland3.9
skin5
small intestine6.7
spleen7.4
stomach8.1
testis5.1
thyroid gland7
urinary bladder5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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