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> Protein (NX_Q8TB24)
Protein (NX_Q8TB24)
Protein
Gene SymbolRIN3 to neXtProt (NX_Q8TB24)
DescriptionRas and Rab interactor 3
Chromosome14
Location14q32.12 (92980118 ~ 93155339) to Ensembl
Sequene Features : Isoforms 2, Variants 133, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of GTPase activity
.signal transduction
.endocytosis
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.GTPase activator activity
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
.early endosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 133 0
2014-09-19protein level
2 96 0
2014-05-27protein level
2 96 0
2014-02-25protein level
2 95 0
2013-12-09protein level
2 66 0
2013-11-01protein level
2 65 0
2013-09-12protein level
2 65 0
2013-08-17protein level
2 65 0
2013-07-15protein level
2 62 0
2013-06-11protein level
2 62 0
2013-02-12protein level
2 37 0
2012-12-20protein level
2 37 0
2012-10-30protein level
2 35 0
2012-10-07protein level
2 35 0
2012-08-24protein level
2 33 0
2012-07-28protein level
2 32 0
2012-06-08protein level
2 9 0
2012-05-07protein level
2 9 0
2012-04-10protein level
2 9 0
2012-01-13protein level
2 9 0
2011-12-20protein level
2 9 0
2011-11-11protein level
2 9 0
2011-08-23protein level
2 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TB24-1
6 38 0 107784.4641
NX_Q8TB24-4
3 38 0 98675.9566
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1570523,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1570523,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
3 EBI-1570523,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood122
bone marrow266
brain12
cervix20
connective tissue33
embryonic tissue32
eye9
heart22
intestine12
kidney52
liver53
lung29
lymph node33
nerve64
ovary29
pancreas9
placenta74
prostate31
skin4
spleen337
testis13
thymus75
trachea19
uterus8
Health State
TissuesTPM*
normal36
chondrosarcoma12
colorectal tumor8
germ cell tumor30
glioma74
kidney tumor14
leukemia232
liver tumor20
lung tumor9
non-neoplasia51
ovarian tumor39
pancreatic tumor19
prostate cancer38
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult27
embryoid body42
blastocyst16
neonate32
fetus52
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.6
adrenal gland8
appendix17.3
bone marrow38.3
cerebral cortex4
colon8.9
duodenum6.8
esophagus9.6
gallbladder12.6
heart muscle7.2
kidney4.3
liver6.6
lung14.9
lymph node13.5
ovary8.1
pancreas1.4
placenta9.2
prostate4.6
salivary gland4.1
skin3.5
small intestine8.7
spleen30.9
stomach4.8
testis12.3
thyroid gland3.6
urinary bladder11.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610223, gene) Ras and rab interactor 3; RIN3OMIM


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