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> Protein (NX_Q8TBC4)
Protein (NX_Q8TBC4)
Protein
Gene SymbolUBA3 to neXtProt (NX_Q8TBC4)
DescriptionNEDD8-activating enzyme E1 catalytic subunit
Chromosome3
Location3p14.1 (69103881 ~ 69129559) to Ensembl
Sequene Features : Isoforms 2, Variants 49, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell cycle
.protein neddylation
.innate immune response
  + 4 more...
.protein heterodimerization activity
.NEDD8 activating enzyme activity
.acid-amino acid ligase activity
.ATP binding
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 49 10
2014-09-19protein level
2 40 10
2014-05-27protein level
2 40 10
2014-02-25protein level
2 40 10
2013-12-09protein level
2 32 10
2013-11-01protein level
2 28 8
2013-09-12protein level
2 28 7
2013-08-17protein level
2 28 7
2013-07-15protein level
2 20 1
2013-06-11protein level
2 20 1
2013-02-12protein level
2 10 2
2012-12-20protein level
2 9 2
2012-10-30protein level
2 13 2
2012-10-07protein level
2 13 1
2012-08-24protein level
2 9 1
2012-07-28protein level
2 9 1
2012-06-08protein level
2 35 1
2012-05-07protein level
2 34 1
2012-04-10protein level
2 34 1
2012-01-13protein level
2 32 1
2011-12-20protein level
2 32 1
2011-11-11protein level
2 32 0
2011-08-23protein level
2 32 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TBC4-1
3 19 0 51819.1888
NX_Q8TBC4-2
1 19 0 50040.1466
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717567,EBI-725233 IMPA2  
  .inositol phosphate dephosphorylation
.phosphatidylinositol phosphorylation
.small molecule metabolic process
  + 4 more...
.inositol monophosphate 4-phosphatase activity
.inositol monophosphate 3-phosphatase activity
.metal ion binding
  + 2 more...
.cytosol
.cytoplasm
2 EBI-717567,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
3 EBI-717567,EBI-1041660 UBE2M  
  .protein neddylation
.innate immune response
.positive regulation of neuron apoptotic process
  + 4 more...
.NEDD8 transferase activity
.ribosomal S6-glutamic acid ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.cytosol
.cytoplasm
4 EBI-717567,EBI-7097057 CPNE2  
  .N/A .N/A .extracellular exosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland151
ascites125
bladder133
blood196
bone41
bone marrow143
brain105
cervix226
connective tissue107
embryonic tissue98
esophagus148
eye62
heart212
intestine30
kidney118
liver53
lung71
lymph node144
mammary gland59
mouth75
muscle94
nerve128
ovary68
pancreas79
parathyroid145
pharynx220
pituitary gland60
placenta98
prostate31
skin90
spleen93
stomach125
testis41
thymus125
thyroid107
trachea115
umbilical cord145
uterus99
vascular367
Health State
TissuesTPM*
normal103
adrenal tumor158
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma48
colorectal tumor17
esophageal tumor173
gastrointestinal tumor67
germ cell tumor98
glioma46
head and neck tumor52
kidney tumor145
leukemia105
liver tumor62
lung tumor58
lymphoma41
non-neoplasia93
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS118
prostate cancer28
retinoblastoma43
skin tumor63
soft tissue/muscle tissue tumor79
uterine tumor122
Developmental Stage
TissuesTPM*
adult73
embryoid body100
blastocyst65
neonate225
fetus100
infant85
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.8
adrenal gland30.8
appendix41.3
bone marrow19.9
cerebral cortex32
colon30.8
duodenum26.7
esophagus32.9
gallbladder31.5
heart muscle48.8
kidney26.7
liver13.3
lung29
lymph node45.7
ovary28.2
pancreas8.4
placenta37.3
prostate34.8
salivary gland32.3
skin35.1
small intestine27.9
spleen32.9
stomach24.5
testis23.9
thyroid gland27
urinary bladder42.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603172, gene) Ubiquitin-activating enzyme e1c; UBE1COMIM


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