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> Protein (NX_Q8TBK6)
Protein (NX_Q8TBK6)
Protein
Gene SymbolZCCHC10 to neXtProt (NX_Q8TBK6)
DescriptionZinc finger CCHC domain-containing protein 10
Chromosome5
Location5q31.1 (132332677 ~ 132362296) to Ensembl
Sequene Features : Isoforms 2, Variants 13, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .zinc ion binding
.nucleic acid binding
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 13 0
2014-09-19protein level
2 11 0
2014-05-27protein level
2 11 0
2014-02-25protein level
2 11 0
2013-12-09protein level
2 11 0
2013-11-01protein level
2 10 0
2013-09-12protein level
2 10 0
2013-08-17protein level
2 10 0
2013-07-15protein level
2 7 0
2013-06-11protein level
2 7 0
2013-02-12protein level
2 5 0
2012-12-20protein level
2 5 0
2012-10-30protein level
2 4 0
2012-10-07protein level
2 4 0
2012-08-24transcript level
2 3 0
2012-07-28transcript level
2 3 0
2012-06-08transcript level
2 3 0
2012-05-07transcript level
2 3 0
2012-04-10transcript level
2 3 0
2012-01-13transcript level
2 0 0
2011-12-20transcript level
2 0 0
2011-11-11transcript level
2 0 0
2011-08-23transcript level
2 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TBK6-1
2 3 0 20954.0758
NX_Q8TBK6-2
0 3 0 18398.679
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-597063,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-597063,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-597063,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
4 EBI-597063,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
5 EBI-597063,EBI-536866 NUDT14  
  .N/A .ADP-ribose diphosphatase activity
.metal ion binding
.UDP-sugar diphosphatase activity
.extracellular exosome
.cytoplasm
6 EBI-597063,EBI-10197451 EPB41  
  .positive regulation of protein binding
.cortical actin cytoskeleton organization
.actin cytoskeleton organization
.blood circulation
.spectrin binding
.1-phosphatidylinositol binding
.structural constituent of cytoskeleton
.protein complex
.intracellular membrane-bounded organelle
.cortical cytoskeleton
  + 6 more...
7 EBI-597063,EBI-1047946 PTPN3  
  .regulation of sodium ion transmembrane transporter activity
.regulation of membrane depolarization during action potential
.liver regeneration
  + 4 more...
.ATPase binding
.sodium channel regulator activity
.protein tyrosine phosphatase activity
.phosphotyrosine binding
.cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
8 EBI-597063,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
9 EBI-597063,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
10 EBI-597063,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
11 EBI-597063,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
12 EBI-597063,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
13 EBI-597063,EBI-948630 DZIP3  
  .protein polyubiquitination .poly(A) RNA binding
.polyubiquitin binding
.phosphatase binding
  + 4 more...
.cytoplasm
14 EBI-597063,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
15 EBI-597063,EBI-741705 TCEB3B  
  .protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of DNA-templated transcription, elongation
.transcription elongation from RNA polymerase II promoter
.transcription from RNA polymerase II promoter
.DNA binding .elongin complex
.integral component of membrane
16 EBI-597063,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
17 EBI-597063,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
18 EBI-597063,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
19 EBI-597063,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
20 EBI-597063,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
21 EBI-597063,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
22 EBI-597063,EBI-745680 STAC3  
  .skeletal muscle fiber development
.intracellular signal transduction
.neuromuscular synaptic transmission
.skeletal muscle contraction
.metal ion binding
.identical protein binding
.N/A
23 EBI-597063,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
24 EBI-597063,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
25 EBI-597063,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
26 EBI-597063,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
27 EBI-597063,EBI-747398 SFMBT1  
  .negative regulation of muscle organ development
.negative regulation of transcription, DNA-templated
.cell differentiation
  + 3 more...
.histone binding
.transcription corepressor activity
.nucleoplasm
.nucleus
28 EBI-597063,EBI-10186082 DACH1  
  .negative regulation of DNA biosynthetic process
.negative regulation of cell proliferation involved in contact inhibition
.negative regulation of fibroblast proliferation
  + 7 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
.intracellular membrane-bounded organelle
.cytoplasm
.nucleolus
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder167
blood16
bone13
bone marrow20
brain21
cervix20
connective tissue6
embryonic tissue37
eye33
heart55
intestine25
kidney47
liver24
lung14
lymph22
lymph node77
mammary gland52
muscle47
ovary29
pancreas18
pharynx73
placenta77
prostate26
salivary gland49
skin28
spleen56
testis36
thymus12
trachea19
uterus25
vascular96
Health State
TissuesTPM*
normal37
bladder carcinoma227
breast (mammary gland) tumor32
cervical tumor28
colorectal tumor8
gastrointestinal tumor16
germ cell tumor34
glioma18
kidney tumor58
leukemia42
liver tumor20
lymphoma27
non-neoplasia20
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma64
skin tumor39
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult26
embryoid body28
blastocyst48
fetus32
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.4
adrenal gland14.5
appendix19.5
bone marrow17.9
cerebral cortex9.6
colon25.3
duodenum14.9
esophagus15.1
gallbladder16.5
heart muscle14.2
kidney16.9
liver14
lung15.1
lymph node28.6
ovary12.6
pancreas4.9
placenta18.6
prostate11.8
salivary gland8.6
skin9.2
small intestine14.9
spleen13.8
stomach17.4
testis22.1
thyroid gland11.6
urinary bladder21.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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