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> Protein (NX_Q8TC07)
Protein (NX_Q8TC07)
Protein
Gene SymbolTBC1D15 to neXtProt (NX_Q8TC07)
DescriptionTBC1 domain family member 15
Chromosome12
Location12q21.1 (72233487 ~ 72320629) to Ensembl
Sequene Features : Isoforms 3, Variants 77, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of GTPase activity
.regulation of GTPase activity
.GTPase activator activity .extracellular exosome
.mitochondrion
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 77 22
2014-09-19protein level
3 64 22
2014-05-27protein level
3 64 22
2014-02-25protein level
3 64 22
2013-12-09protein level
3 51 22
2013-11-01protein level
3 51 19
2013-09-12protein level
3 51 20
2013-08-17protein level
3 51 20
2013-07-15protein level
3 31 5
2013-06-11protein level
3 31 5
2013-02-12protein level
2 12 14
2012-12-20protein level
2 12 14
2012-10-30protein level
2 16 14
2012-10-07protein level
2 16 7
2012-08-24protein level
2 15 7
2012-07-28protein level
2 15 7
2012-06-08protein level
2 19 7
2012-05-07protein level
2 15 7
2012-04-10protein level
2 15 7
2012-01-13protein level
2 6 7
2011-12-20protein level
2 6 7
2011-11-11protein level
2 6 7
2011-08-23protein level
2 6 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TC07-1
2 34 0 79439.4515
NX_Q8TC07-2
0 35 0 77345.2464
NX_Q8TC07-3
2 33 0 78521.7057
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1048247,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-1048247,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
3 EBI-1048247,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
4 EBI-1048247,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
5 EBI-1048247,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
6 EBI-1048247,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
7 EBI-1048247,EBI-749920 CALCOCO1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.armadillo repeat domain binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 6 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nucleus
.nuclear chromatin
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites125
bladder33
blood122
bone83
bone marrow61
brain65
cervix61
connective tissue73
embryonic tissue4
esophagus99
eye57
heart67
intestine43
kidney75
larynx42
liver38
lung35
lymph22
lymph node11
mammary gland52
mouth136
muscle37
ovary19
pancreas28
pituitary gland121
placenta84
prostate63
skin47
spleen93
stomach125
testis142
thymus288
thyroid21
tonsil58
trachea135
umbilical cord72
uterus99
vascular116
Health State
TissuesTPM*
normal72
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma84
colorectal tumor35
esophageal tumor115
gastrointestinal tumor101
germ cell tumor110
glioma55
head and neck tumor74
kidney tumor87
leukemia31
liver tumor41
lung tumor29
lymphoma41
non-neoplasia72
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor63
uterine tumor110
Developmental Stage
TissuesTPM*
adult48
blastocyst16
neonate160
fetus62
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.5
adrenal gland35.8
appendix25.6
bone marrow45.8
cerebral cortex22.2
colon21.3
duodenum18.8
esophagus21.9
gallbladder31
heart muscle16.6
kidney25.2
liver22.1
lung26.8
lymph node31
ovary30.5
pancreas15.6
placenta29.1
prostate25.3
salivary gland22.6
skin18
small intestine24.8
spleen27.2
stomach21.3
testis30.9
thyroid gland34.7
urinary bladder26.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612662, gene) Tbc1 domain family, member 15; TBC1D15OMIM


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