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> Protein (NX_Q8TCT8)
Protein (NX_Q8TCT8)
Protein
Gene SymbolSPPL2A to neXtProt (NX_Q8TCT8)
DescriptionSignal peptide peptidase-like 2A
Chromosome15
Location15q21.2 (50999506 ~ 51058005) to Ensembl
Sequene Features : Isoforms 1, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of immune response
.membrane protein intracellular domain proteolysis
.membrane protein ectodomain proteolysis
.protein homodimerization activity
.aspartic-type endopeptidase activity
.integral component of lumenal side of endoplasmic reticulum membrane
.integral component of cytoplasmic side of endoplasmic reticulum membrane
.extracellular exosome
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 56 8
2014-09-19protein level
1 45 8
2014-05-27protein level
1 45 8
2014-02-25protein level
1 44 8
2013-12-09protein level
1 29 7
2013-11-01protein level
1 29 7
2013-09-12protein level
1 29 7
2013-08-17protein level
1 29 7
2013-07-15protein level
1 21 7
2013-06-11protein level
1 21 7
2013-02-12protein level
1 14 7
2012-12-20protein level
1 13 7
2012-10-30protein level
1 17 7
2012-10-07protein level
1 17 7
2012-08-24protein level
1 12 7
2012-07-28protein level
1 12 7
2012-06-08protein level
1 18 7
2012-05-07protein level
1 18 7
2012-04-10protein level
1 18 7
2012-01-13protein level
1 14 7
2011-12-20protein level
1 14 7
2011-11-11protein level
1 14 0
2011-08-23protein level
1 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TCT8-1
18 0 0 58104.15
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-750784,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites25
blood16
bone13
bone marrow41
brain13
cervix41
connective tissue268
ear186
embryonic tissue14
esophagus49
eye19
heart44
intestine51
kidney42
larynx42
liver19
lung29
lymph22
lymph node33
mammary gland39
muscle28
ovary9
pancreas37
parathyroid145
placenta45
prostate21
skin4
spleen56
stomach10
testis39
thymus62
thyroid85
trachea19
uterus4
vascular77
Health State
TissuesTPM*
normal31
adrenal tumor237
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma36
colorectal tumor44
esophageal tumor57
gastrointestinal tumor8
germ cell tumor26
glioma9
head and neck tumor37
kidney tumor29
leukemia21
lung tumor19
lymphoma41
non-neoplasia82
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS47
prostate cancer9
soft tissue/muscle tissue tumor247
Developmental Stage
TissuesTPM*
adult47
fetus35
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.4
adrenal gland29.5
appendix63.3
bone marrow35.4
cerebral cortex13
colon87.6
duodenum73.2
esophagus32.2
gallbladder50.8
heart muscle33.2
kidney46.6
liver52.3
lung37.5
lymph node46.2
ovary15.1
pancreas33
placenta57.9
prostate34.3
salivary gland31.7
skin31.6
small intestine69.6
spleen35.5
stomach42.1
testis22.9
thyroid gland41.9
urinary bladder46.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastLow
bronchusMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Low
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608238, gene) Signal peptide peptidase-like 2aOMIM


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