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> Protein (NX_Q8TD10)
Protein (NX_Q8TD10)
Protein
Gene SymbolMIPOL1 to neXtProt (NX_Q8TD10)
DescriptionMirror-image polydactyly gene 1 protein
Chromosome14
Location14q13.3 (37667118 ~ 38021566) to Ensembl
Sequene Features : Isoforms 3, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 64 0
2014-09-19protein level
3 46 0
2014-05-27protein level
3 46 0
2014-02-25protein level
3 45 0
2013-12-09protein level
3 35 0
2013-11-01protein level
3 34 0
2013-09-12protein level
3 34 0
2013-08-17protein level
3 34 0
2013-07-15transcript level
3 18 0
2013-06-11transcript level
3 18 0
2013-02-12transcript level
3 5 0
2012-12-20transcript level
3 5 0
2012-10-30transcript level
3 8 0
2012-10-07transcript level
3 8 0
2012-08-24transcript level
3 8 0
2012-07-28transcript level
3 8 0
2012-06-08transcript level
3 1 0
2012-05-07transcript level
3 1 0
2012-04-10transcript level
3 1 0
2012-01-13transcript level
3 1 0
2011-12-20transcript level
3 1 0
2011-11-11transcript level
3 1 0
2011-08-23transcript level
3 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TD10-1
1 21 0 51504.7676
NX_Q8TD10-2
0 16 0 30255.5049
NX_Q8TD10-3
0 5 0 19887.627
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2548751,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
2 EBI-2548751,EBI-2880203 NEBL  
  .cardiac muscle thin filament assembly .actin filament binding
.filamin binding
.structural constituent of muscle
  + 2 more...
.extracellular exosome
.I band
.Z disc
.stress fiber
3 EBI-2548751,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
4 EBI-2548751,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
5 EBI-2548751,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
6 EBI-2548751,EBI-356673 CCT3  
  .toxin transport
.'de novo' posttranslational protein folding
.pore complex assembly
  + 3 more...
.unfolded protein binding
.poly(A) RNA binding
.ATP binding
.extracellular exosome
.cell body
.plasma membrane
  + 6 more...
7 EBI-2548751,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
8 EBI-2548751,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
9 EBI-2548751,EBI-473850 UBE2K  
  .protein K48-linked ubiquitination
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.intermediate filament cytoskeleton
.actin cytoskeleton
  + 2 more...
10 EBI-2548751,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
11 EBI-2548751,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
12 EBI-2548751,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
13 EBI-2548751,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
14 EBI-2548751,EBI-747711 DIEXF  
  .multicellular organismal development
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding
.U3 snoRNA binding
.rRNA binding
.small-subunit processome
.nucleolus
15 EBI-2548751,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
16 EBI-2548751,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
17 EBI-2548751,EBI-6952711 MYLIP  
  .positive regulation of protein catabolic process
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cholesterol homeostasis
  + 6 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
  + 2 more...
.extrinsic component of membrane
.plasma membrane
.cytoskeleton
  + 2 more...
18 EBI-2548751,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
19 EBI-2548751,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
20 EBI-2548751,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
21 EBI-2548751,EBI-769261 EAF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
22 EBI-2548751,EBI-1105153 PPP1R13B  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
.N/A .plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
23 EBI-2548751,EBI-10295431 SSX3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
24 EBI-2548751,EBI-740781 TCHP  
  .negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
25 EBI-2548751,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
26 EBI-2548751,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
27 EBI-2548751,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
28 EBI-2548751,EBI-10274410 TTC12  
  .N/A .N/A .N/A
29 EBI-2548751,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
30 EBI-2548751,EBI-954308 USH1C  
  .equilibrioception
.sensory perception of light stimulus
.photoreceptor cell maintenance
  + 5 more...
.spectrin binding .synapse
.apical part of cell
.stereocilium
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
bone13
brain2
connective tissue26
embryonic tissue4
eye9
kidney4
larynx42
lung2
mouth15
muscle18
ovary9
pancreas32
prostate15
skin9
spleen18
stomach20
testis9
thyroid42
umbilical cord72
vascular19
Health State
TissuesTPM*
normal6
bladder carcinoma113
chondrosarcoma12
gastrointestinal tumor16
head and neck tumor29
leukemia10
pancreatic tumor19
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult9
neonate32
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.3
adrenal gland4
appendix1.9
cerebral cortex3
colon3.5
duodenum2.1
esophagus6.1
gallbladder6.2
heart muscle3.1
kidney4.9
liver2.3
lung4
ovary9.2
pancreas1.9
placenta1.4
prostate8.3
salivary gland2.6
skin2.3
small intestine2.3
spleen1.7
stomach4.5
testis12.7
thyroid gland9.5
urinary bladder5.2
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxLow
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaLow
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Low
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606850, gene) Mirror-image polydactyly gene 1; MIPOL1OMIM


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2014-2019 (C) Yonsei Proteome Research Center