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> Protein (NX_Q8TD19)
Protein (NX_Q8TD19)
Protein
Gene SymbolNEK9 to neXtProt (NX_Q8TD19)
DescriptionSerine/threonine-protein kinase Nek9
Chromosome14
Location14q24.3 (75548822 ~ 75594047) to Ensembl
Sequene Features : Isoforms 1, Variants 84, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.mitotic nuclear envelope disassembly
.mitotic nuclear division
  + 2 more...
.metal ion binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 84 22
2014-09-19protein level
1 71 22
2014-05-27protein level
1 71 22
2014-02-25protein level
1 71 22
2013-12-09protein level
1 50 22
2013-11-01protein level
1 47 21
2013-09-12protein level
1 47 21
2013-08-17protein level
1 47 21
2013-07-15protein level
1 35 19
2013-06-11protein level
1 35 19
2013-02-12protein level
1 20 38
2012-12-20protein level
1 21 38
2012-10-30protein level
1 28 38
2012-10-07protein level
1 28 38
2012-08-24protein level
1 24 38
2012-07-28protein level
1 23 38
2012-06-08protein level
1 28 38
2012-05-07protein level
1 28 38
2012-04-10protein level
1 28 38
2012-01-13protein level
1 12 38
2011-12-20protein level
1 12 38
2011-11-11protein level
1 12 38
2011-08-23protein level
1 12 38
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TD19-1
43 0 0 107099.9134
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1044009,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-1044009,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
3 EBI-1044009,EBI-476768 PLK1  
  .regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
4 EBI-1044009,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
5 EBI-1044009,EBI-349105 DYNLL1  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of phosphorylation
  + 15 more...
.nitric-oxide synthase regulator activity
.motor activity
.ciliary tip
.mitotic spindle
.primary cilium
  + 11 more...
6 EBI-1044009,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
7 EBI-1044009,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
8 EBI-1044009,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland60
blood40
bone125
brain37
cervix123
connective tissue33
embryonic tissue75
esophagus99
eye105
heart100
intestine73
kidney28
larynx42
liver58
lung95
lymph67
lymph node222
mammary gland85
mouth15
muscle18
nerve64
ovary118
pancreas23
parathyroid339
pharynx49
pituitary gland121
placenta81
prostate94
skin85
spleen56
stomach83
testis43
thymus12
thyroid42
trachea19
uterus99
vascular38
Health State
TissuesTPM*
normal72
breast (mammary gland) tumor96
cervical tumor173
chondrosarcoma120
colorectal tumor97
esophageal tumor115
gastrointestinal tumor42
germ cell tumor11
glioma130
head and neck tumor7
kidney tumor43
leukemia52
liver tumor52
lung tumor38
lymphoma69
non-neoplasia41
ovarian tumor157
pancreatic tumor19
primitive neuroectodermal tumor of the CNS55
prostate cancer86
retinoblastoma86
skin tumor95
soft tissue/muscle tissue tumor79
uterine tumor66
Developmental Stage
TissuesTPM*
adult80
embryoid body85
blastocyst97
fetus86
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.2
adrenal gland33.2
appendix28.8
bone marrow9.6
cerebral cortex16.2
colon20.5
duodenum20.8
esophagus22
gallbladder28.9
heart muscle35.9
kidney22.5
liver17.5
lung25.6
lymph node33.5
ovary46.9
pancreas10.5
placenta24.3
prostate33.1
salivary gland16.4
skin20.3
small intestine21.3
spleen31.7
stomach18.5
testis32.6
thyroid gland26.7
urinary bladder26.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609798, gene) Never in mitosis gene a-related kinase 9; NEK9OMIM


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