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> Protein (NX_Q8TD31)
Protein (NX_Q8TD31)
Protein
Gene SymbolCCHCR1 to neXtProt (NX_Q8TD31)
DescriptionCoiled-coil alpha-helical rod protein 1
Chromosome6
Location6p21.33 (31110216 ~ 31126015) to Ensembl
Sequene Features : Isoforms 3, Variants 82, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 82 2
2014-09-19protein level
3 63 2
2014-05-27protein level
3 63 2
2014-02-25protein level
3 43 2
2013-12-09protein level
3 30 2
2013-11-01protein level
3 30 1
2013-09-12protein level
3 30 1
2013-08-17protein level
3 30 1
2013-07-15protein level
2 30 0
2013-06-11protein level
2 30 0
2013-02-12protein level
2 30 2
2012-12-20protein level
2 31 2
2012-10-30protein level
2 33 2
2012-10-07protein level
2 33 1
2012-08-24protein level
2 33 1
2012-07-28protein level
2 33 1
2012-06-08protein level
2 44 1
2012-05-07protein level
2 44 1
2012-04-10protein level
2 41 1
2012-01-13protein level
2 29 1
2011-12-20protein level
2 29 1
2011-11-11protein level
2 29 1
2011-08-23protein level
2 27 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TD31-1
1 36 0 88617.0545
NX_Q8TD31-2
1 39 0 98946.1707
NX_Q8TD31-3
1 38 0 95087.1211
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10175300,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-10175300,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
3 EBI-10175300,EBI-1050253 CTAGE5  
  .positive regulation of catalytic activity .enzyme activator activity .membrane
4 EBI-10175300,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
5 EBI-10175300,EBI-748664 HSBP1  
  .regulation of cellular response to heat
.endodermal cell differentiation
.cellular response to heat
  + 2 more...
.transcription corepressor activity .cytoskeleton
.nucleoplasm
.nucleus
6 EBI-10175300,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
7 EBI-10175300,EBI-355607 TPM3  
  .muscle filament sliding
.muscle contraction
.movement of cell or subcellular component
.N/A .extracellular exosome
.muscle thin filament tropomyosin
.cytoskeleton
  + 2 more...
8 EBI-10175300,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
9 EBI-10175300,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
10 EBI-10175300,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
11 EBI-10175300,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
12 EBI-10175300,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
13 EBI-10175300,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
14 EBI-10175300,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
15 EBI-10175300,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
16 EBI-10175300,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
17 EBI-10175300,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
18 EBI-10175300,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
19 EBI-10175300,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
20 EBI-10175300,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
21 EBI-10175300,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
22 EBI-10175300,EBI-946029 C1orf94  
  .N/A .N/A .N/A
23 EBI-10175300,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
24 EBI-10175300,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
25 EBI-10175300,EBI-10180409 TEKT1  
  .N/A .N/A .cilium
.microtubule
.cytoplasm
.nucleus
26 EBI-10175300,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
27 EBI-10175300,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
28 EBI-10175300,EBI-740272 RBM17  
  .alternative mRNA splicing, via spliceosome .RNA binding
.nucleotide binding
.spliceosomal complex
.nucleoplasm
29 EBI-10175300,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
30 EBI-10175300,EBI-10187928 ZFYVE19  
  .cell division
.negative regulation of cytokinesis
.abscission
.cell cycle
.phosphatidylinositol-3-phosphate binding
.zinc ion binding
.cleavage furrow
.midbody
.centrosome
.cytoplasm
31 EBI-10175300,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
32 EBI-10175300,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
33 EBI-10175300,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
34 EBI-10175300,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
35 EBI-10175300,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
36 EBI-10175300,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
37 EBI-10175300,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
38 EBI-10175300,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
39 EBI-10175300,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
40 EBI-10175300,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
41 EBI-10175300,EBI-719716 NINL  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.calcium ion binding .microtubule
.cytosol
.microtubule organizing center
42 EBI-10175300,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
43 EBI-10175300,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
44 EBI-10175300,EBI-744782 NME7  
  .left/right pattern formation
.ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
  + 6 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.ciliary basal body
.centrosome
45 EBI-10175300,EBI-742610 MAD1L1  
  .regulation of metaphase plate congression
.cell division
.small GTPase mediated signal transduction
  + 4 more...
.N/A .mitotic spindle
.actin cytoskeleton
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder66
blood40
bone13
bone marrow41
brain40
cervix185
connective tissue6
embryonic tissue51
eye28
heart44
intestine51
kidney23
larynx42
liver14
lung35
lymph45
lymph node33
mammary gland13
mouth75
ovary59
pancreas4
parathyroid48
placenta10
prostate26
skin37
spleen56
stomach10
testis142
thymus238
tonsil58
trachea19
uterus43
Health State
TissuesTPM*
normal38
breast (mammary gland) tumor21
cervical tumor144
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor42
germ cell tumor64
glioma55
head and neck tumor37
kidney tumor29
leukemia52
liver tumor20
lung tumor68
lymphoma69
non-neoplasia10
ovarian tumor52
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma86
skin tumor47
soft tissue/muscle tissue tumor39
uterine tumor11
Developmental Stage
TissuesTPM*
adult28
embryoid body57
blastocyst48
neonate64
fetus25
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.7
adrenal gland6.6
appendix9.7
bone marrow10
cerebral cortex5.4
colon13
duodenum15.7
esophagus7.3
gallbladder8.6
heart muscle6.8
kidney10.8
liver5
lung7
lymph node12.7
ovary12.3
pancreas6.8
placenta3.9
prostate14
salivary gland8.3
skin15.2
small intestine13.9
spleen10.8
stomach14.3
testis102.9
thyroid gland11.1
urinary bladder6.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605310, gene) Coiled-coil alpha-helical rod protein 1; CCHCR1OMIM


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