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> Protein (NX_Q8TDN4)
Protein (NX_Q8TDN4)
Protein
Gene SymbolCABLES1 to neXtProt (NX_Q8TDN4)
DescriptionCDK5 and ABL1 enzyme substrate 1
Chromosome18
Location18q11.2 (20714528 ~ 20840431) to Ensembl
Sequene Features : Isoforms 4, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell cycle
.cell division
.blood coagulation
  + 2 more...
.N/A .cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 52 4
2014-09-19protein level
4 43 4
2014-05-27protein level
4 43 4
2014-02-25protein level
4 43 4
2013-12-09protein level
4 32 4
2013-11-01protein level
4 30 4
2013-09-12protein level
4 30 4
2013-08-17protein level
4 30 4
2013-07-15protein level
4 14 4
2013-06-11protein level
4 14 4
2013-02-12protein level
4 8 35
2012-12-20protein level
3 10 28
2012-10-30protein level
3 15 28
2012-10-07protein level
3 15 15
2012-08-24protein level
3 15 15
2012-07-28protein level
3 14 15
2012-06-08protein level
3 16 15
2012-05-07protein level
3 13 15
2012-04-10protein level
3 13 15
2012-01-13protein level
3 9 15
2011-12-20protein level
3 9 15
2011-11-11protein level
3 9 15
2011-08-23protein level
3 9 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TDN4-1
8 12 1 67556.5216
NX_Q8TDN4-2
1 12 1 41844.8457
NX_Q8TDN4-3
0 2 1 15845.5665
NX_Q8TDN4-4
0 10 1 34570.9643
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-604615,EBI-1041567 CDK5  
  .positive regulation of actin cytoskeleton reorganization
.regulation of synaptic vesicle recycling
.negative regulation of neuron death
  + 63 more...
.tau-protein kinase activity
.ErbB-3 class receptor binding
.acetylcholine receptor activator activity
  + 6 more...
.postsynaptic membrane
.perikaryon
.neuronal cell body
  + 14 more...
2 EBI-604615,EBI-2400586 TP63  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cellular senescence
.negative regulation of mesoderm development
  + 54 more...
.WW domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 10 more...
.dendrite
.cytosol
.rough endoplasmic reticulum
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites100
bladder66
brain28
cervix20
connective tissue20
embryonic tissue14
eye43
heart89
intestine60
kidney37
larynx255
liver38
lung53
mammary gland46
nerve64
ovary29
pancreas51
parathyroid242
pharynx24
placenta49
prostate21
skin94
stomach125
testis6
thymus12
thyroid42
umbilical cord145
uterus47
vascular19
Health State
TissuesTPM*
normal30
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma36
colorectal tumor115
gastrointestinal tumor135
germ cell tumor15
glioma37
head and neck tumor37
kidney tumor43
leukemia10
liver tumor72
lung tumor116
non-neoplasia31
ovarian tumor26
pancreatic tumor38
prostate cancer38
retinoblastoma21
skin tumor119
soft tissue/muscle tissue tumor7
uterine tumor110
Developmental Stage
TissuesTPM*
adult45
embryoid body14
blastocyst16
neonate64
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.1
adrenal gland4.4
appendix3.1
bone marrow2.8
cerebral cortex14.7
colon5.1
duodenum7.8
esophagus12.8
gallbladder7.4
heart muscle4.5
kidney13.9
liver4.7
lung22.7
lymph node3.6
ovary4.6
pancreas1.3
placenta11.5
prostate3.3
salivary gland18.1
skin15.5
small intestine7
spleen2.8
stomach12.3
testis5.1
thyroid gland23.8
urinary bladder9.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*609194, gene) Cdk5 and abl enzyme substrate 1; CABLES1OMIM


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