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> Protein (NX_Q8TDR4)
Protein (NX_Q8TDR4)
Protein
Gene SymbolTCP10L to neXtProt (NX_Q8TDR4)
DescriptionT-complex protein 10A homolog 2
Chromosome21
Location21q22.11 (33948862 ~ 33959683) to Ensembl
Sequene Features : Isoforms 1, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription from RNA polymerase II promoter .repressing transcription factor binding
.protein self-association
.identical protein binding
.RNA polymerase II transcription corepressor activity
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 29 0
2014-09-19protein level
1 23 0
2014-05-27protein level
1 23 0
2014-02-25protein level
1 23 0
2013-12-09protein level
1 17 0
2013-11-01protein level
1 15 0
2013-09-12protein level
1 15 0
2013-08-17protein level
1 15 0
2013-07-15protein level
1 8 0
2013-06-11protein level
1 8 0
2013-02-12protein level
1 5 0
2012-12-20protein level
1 7 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 8 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 8 0
2012-04-10protein level
1 8 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11transcript level
1 4 0
2011-08-23transcript level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TDR4-1
9 0 0 23848.2169
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3923210,EBI-77293 DAPK3  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 23 more...
.leucine zipper domain binding
.protein homodimerization activity
.identical protein binding
  + 5 more...
.membrane raft
.PML body
.cytoplasm
.nucleus
2 EBI-3923210,EBI-3943670 MXD4  
  .negative regulation of cell proliferation
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain8
embryonic tissue4
eye9
liver9
lung5
lymph node11
ovary9
testis124
Health State
TissuesTPM*
normal12
germ cell tumor68
liver tumor20
ovarian tumor13
Developmental Stage
TissuesTPM*
adult6
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex1.1
heart muscle1.5
liver9
ovary1.3
testis115.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608365, gene) T-complex protein 10-like; TCP10LOMIM


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