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> Protein (NX_Q8TES7)
Protein (NX_Q8TES7)
Protein
Gene SymbolFBF1 to neXtProt (NX_Q8TES7)
DescriptionFas-binding factor 1
Chromosome17
Location17q25.1 (73905655 ~ 73937221) to Ensembl
Sequene Features : Isoforms 6, Variants 115, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 115 1
2014-09-19protein level
6 88 1
2014-05-27protein level
6 88 1
2014-02-25protein level
6 87 1
2013-12-09protein level
6 48 1
2013-11-01protein level
6 48 1
2013-09-12protein level
6 48 1
2013-08-17protein level
6 48 1
2013-07-15protein level
6 34 1
2013-06-11protein level
6 34 1
2013-02-12protein level
6 18 18
2012-12-20protein level
6 15 18
2012-10-30protein level
6 28 18
2012-10-07protein level
6 28 3
2012-08-24protein level
6 27 3
2012-07-28protein level
6 27 3
2012-06-08protein level
6 5 3
2012-05-07protein level
6 5 3
2012-04-10protein level
6 5 3
2012-01-13protein level
6 5 3
2011-12-20protein level
6 5 3
2011-11-11protein level
6 5 3
2011-08-23protein level
6 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TES7-1
0 53 0 125369.6003
NX_Q8TES7-2
0 42 0 98582.7988
NX_Q8TES7-3
3 28 0 69135.6479
NX_Q8TES7-4
3 22 0 54757.5814
NX_Q8TES7-5
0 53 0 125411.6108
NX_Q8TES7-6
1 52 0 126963.2468
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10244131,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
2 EBI-10244131,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-10244131,EBI-3909284 GATA1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of transcription regulatory region DNA binding
.cellular response to thyroid hormone stimulus
  + 26 more...
.C2H2 zinc finger domain binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 12 more...
.transcriptional repressor complex
.transcription factor complex
.nucleoplasm
.nucleus
4 EBI-10244131,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
5 EBI-10244131,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
6 EBI-10244131,EBI-748597 CCDC67  
  .multi-ciliated epithelial cell differentiation
.de novo centriole assembly
.cell projection organization
.N/A .deuterosome
.cytoplasm
7 EBI-10244131,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
8 EBI-10244131,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-10244131,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
10 EBI-10244131,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
11 EBI-10244131,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
12 EBI-10244131,EBI-8636434 TTC32  
  .N/A .N/A .N/A
13 EBI-10244131,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
14 EBI-10244131,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
15 EBI-10244131,EBI-742397 TEX11  
  .chiasma assembly
.negative regulation of apoptotic process
.fertilization
  + 6 more...
.N/A .central element
16 EBI-10244131,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
17 EBI-10244131,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
18 EBI-10244131,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
19 EBI-10244131,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
20 EBI-10244131,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
21 EBI-10244131,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
22 EBI-10244131,EBI-739784 CINP  
  .cell division
.cell cycle
.DNA repair
.DNA replication
.N/A .nucleus
23 EBI-10244131,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
24 EBI-10244131,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
25 EBI-10244131,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
26 EBI-10244131,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
27 EBI-10244131,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
28 EBI-10244131,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
29 EBI-10244131,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
30 EBI-10244131,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain9
cervix20
embryonic tissue28
intestine12
kidney4
larynx42
lung14
lymph node11
mammary gland6
muscle103
nerve64
prostate5
skin9
testis27
thyroid42
uterus4
Health State
TissuesTPM*
normal12
bladder carcinoma113
cervical tumor28
chondrosarcoma12
germ cell tumor3
glioma37
head and neck tumor7
kidney tumor14
lung tumor19
non-neoplasia10
soft tissue/muscle tissue tumor63
uterine tumor11
Developmental Stage
TissuesTPM*
adult9
embryoid body71
blastocyst16
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4
adrenal gland4.7
appendix5.7
bone marrow4.5
cerebral cortex5.9
colon2.6
duodenum3.5
esophagus5.3
gallbladder5.2
heart muscle2.1
kidney4.1
lung5
lymph node6.2
ovary5
pancreas2.5
placenta2.3
prostate7
salivary gland4.4
skin17.3
small intestine5.3
spleen7.7
stomach4.6
testis31.4
thyroid gland12.1
urinary bladder3.3
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
breastLow
bronchusMedium
cervix, uterineMedium
colonLow
epididymisHigh
esophagusLow
fallopian tubeLow
gallbladderLow
kidneyMedium
lungLow
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
placentaLow
prostateLow
seminal vesicleLow
skeletal muscleLow
skin 2Low
stomach 1Low
stomach 2Low
testisLow
thyroid glandLow
tonsilMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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