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> Protein (NX_Q8TEW0)
Protein (NX_Q8TEW0)
Protein
Gene SymbolPARD3 to neXtProt (NX_Q8TEW0)
DescriptionPartitioning defective 3 homolog
Chromosome10
Location10p11.21 (34398488 ~ 35104253) to Ensembl
Sequene Features : Isoforms 11, Variants 192, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of epithelial cell polarity
.tight junction assembly
.regulation of cellular localization
  + 18 more...
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.apical part of cell
.axonal growth cone
.protein complex
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
11 192 20
2014-09-19protein level
11 152 20
2014-05-27protein level
11 152 16
2014-02-25protein level
11 152 16
2013-12-09protein level
11 114 16
2013-11-01protein level
11 109 16
2013-09-12protein level
11 109 18
2013-08-17protein level
11 109 18
2013-07-15protein level
11 82 18
2013-06-11protein level
11 82 18
2013-02-12protein level
11 39 204
2012-12-20protein level
10 42 184
2012-10-30protein level
10 48 184
2012-10-07protein level
10 48 20
2012-08-24protein level
10 31 20
2012-07-28protein level
10 31 20
2012-06-08protein level
10 37 20
2012-05-07protein level
10 37 20
2012-04-10protein level
10 37 20
2012-01-13protein level
10 28 20
2011-12-20protein level
10 28 20
2011-11-11protein level
10 28 20
2011-08-23protein level
10 28 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TEW0-1
0 68 0 151329.997
NX_Q8TEW0-10
0 50 0 109848.8703
NX_Q8TEW0-11
0 67 0 149603.2185
NX_Q8TEW0-2
0 68 0 151056.9016
NX_Q8TEW0-3
0 63 0 140985.0377
NX_Q8TEW0-4
0 67 0 146786.6387
NX_Q8TEW0-5
1 62 0 138246.5818
NX_Q8TEW0-6
0 65 0 146186.5103
NX_Q8TEW0-7
0 64 0 141643.152
NX_Q8TEW0-8
0 52 0 113348.6517
NX_Q8TEW0-9
0 49 0 108478.2604
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81968,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-81968,EBI-2903122 CDH5  
  .regulation of establishment of cell polarity
.vascular endothelial growth factor receptor signaling pathway
.cell-cell junction organization
  + 5 more...
.ion channel binding
.beta-catenin binding
.calcium ion binding
.receptor binding
.cell junction
.integral component of membrane
.membrane
  + 4 more...
3 EBI-81968,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
4 EBI-81968,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
5 EBI-81968,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
6 EBI-81968,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
7 EBI-81968,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
8 EBI-81968,EBI-295417 PARD6G  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
9 EBI-81968,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
10 EBI-81968,EBI-81876 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
11 EBI-81968,EBI-742600 F11R  
  .regulation of actin cytoskeleton reorganization
.regulation of membrane permeability
.establishment of endothelial intestinal barrier
  + 17 more...
.PDZ domain binding .extracellular exosome
.slit diaphragm
.cytoplasmic vesicle
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites125
bladder100
blood8
bone83
bone marrow41
brain19
cervix20
connective tissue53
embryonic tissue70
eye105
heart44
intestine43
kidney75
larynx127
liver14
lung53
lymph node11
mammary gland66
mouth120
muscle18
nerve64
ovary98
pancreas32
pharynx49
placenta21
prostate15
salivary gland49
skin37
spleen93
stomach41
testis25
thymus12
thyroid107
trachea19
uterus34
vascular38
Health State
TissuesTPM*
normal33
bladder carcinoma170
breast (mammary gland) tumor53
chondrosarcoma84
colorectal tumor62
gastrointestinal tumor67
germ cell tumor64
glioma74
head and neck tumor134
kidney tumor87
leukemia21
liver tumor20
lung tumor58
non-neoplasia10
ovarian tumor91
pancreatic tumor38
primitive neuroectodermal tumor of the CNS55
prostate cancer9
retinoblastoma64
soft tissue/muscle tissue tumor95
Developmental Stage
TissuesTPM*
adult48
embryoid body57
blastocyst65
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.8
adrenal gland13.5
appendix6.6
cerebral cortex7.8
colon23.3
duodenum12.8
esophagus52.4
gallbladder20
heart muscle11.9
kidney25
liver15.8
lung17.9
lymph node3.2
ovary40.8
pancreas19.6
placenta24.5
prostate18.9
salivary gland13.2
skin49.1
small intestine14.4
spleen5
stomach14
testis21
thyroid gland18.8
urinary bladder19.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606745, gene) Partitioning-defective protein 3, c. elegans, homolog of; PARD3OMIM


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