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> Protein (NX_Q8TEW6)
Protein (NX_Q8TEW6)
Protein
Gene SymbolDOK4 to neXtProt (NX_Q8TEW6)
DescriptionDocking protein 4
Chromosome16
Location16q21 (57505863 ~ 57521239) to Ensembl
Sequene Features : Isoforms 1, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nervous system development
.transmembrane receptor protein tyrosine kinase signaling pathway
.MAPK cascade
.receptor signaling protein activity .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 29 0
2014-09-19protein level
1 25 0
2014-05-27protein level
1 25 0
2014-02-25protein level
1 25 0
2013-12-09protein level
1 17 0
2013-11-01protein level
1 17 0
2013-09-12protein level
1 17 0
2013-08-17protein level
1 17 0
2013-07-15protein level
1 10 0
2013-06-11protein level
1 10 0
2013-02-12protein level
1 7 0
2012-12-20protein level
1 7 0
2012-10-30protein level
1 7 0
2012-10-07protein level
1 7 0
2012-08-24protein level
1 7 0
2012-07-28protein level
1 6 0
2012-06-08protein level
1 8 0
2012-05-07protein level
1 9 0
2012-04-10protein level
1 9 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TEW6-1
14 0 0 37004.4314
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6918542,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-6918542,EBI-2624570 OPRM1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.cellular response to morphine
.response to growth factor
  + 30 more...
.neuropeptide binding
.morphine receptor activity
.G-protein beta-subunit binding
  + 4 more...
.membrane raft
.perikaryon
.neuron projection
  + 8 more...
3 EBI-6918542,EBI-10694655 DOK3  
  .Ras protein signal transduction .N/A .plasma membrane
.cytoplasm
4 EBI-6918542,EBI-1573056 CCM2  
  .endothelial tube morphogenesis
.blood vessel endothelial cell differentiation
.pericardium development
  + 9 more...
.N/A .protein complex
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bone69
bone marrow41
brain153
cervix20
connective tissue60
embryonic tissue61
eye19
heart33
intestine116
kidney66
liver19
lung38
lymph node11
mammary gland19
muscle56
ovary49
pancreas84
pharynx49
pituitary gland60
placenta14
prostate21
skin42
spleen37
stomach52
testis64
thymus25
thyroid21
uterus43
vascular116
Health State
TissuesTPM*
normal65
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma132
colorectal tumor97
gastrointestinal tumor33
germ cell tumor60
glioma74
head and neck tumor22
kidney tumor43
leukemia21
liver tumor10
lung tumor38
non-neoplasia31
ovarian tumor39
pancreatic tumor57
primitive neuroectodermal tumor of the CNS559
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor63
uterine tumor44
Developmental Stage
TissuesTPM*
adult39
embryoid body71
blastocyst48
fetus213
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.2
adrenal gland7.2
appendix8.7
bone marrow1.1
cerebral cortex6.6
colon35.7
duodenum35.5
esophagus16.6
gallbladder18.3
heart muscle10.1
kidney23.8
liver8.7
lung23.3
lymph node3.9
ovary16.5
pancreas6.7
placenta8.9
prostate10.3
salivary gland7.1
skin35.7
small intestine39.6
spleen6.6
stomach32.3
testis7
thyroid gland6.7
urinary bladder12
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusLow
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxLow
ovaryMedium
pancreasHigh
placentaHigh
rectumMedium
salivary glandHigh
seminal vesicleMedium
skin 1Medium
skin 2Low
small intestineHigh
soft tissue 1Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608333, gene) Docking protein 4; DOK4OMIM


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