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	> Protein (NX_Q8TF05) Protein (NX_Q8TF05) Protein Gene Symbol PPP4R1 to neXtProt (NX_Q8TF05) Description Serine/threonine-protein phosphatase 4 regulatory subunit 1 Chromosome 18 Location 18p11.22 (9546789 ~ 9615238) to Ensembl Sequene Features : Isoforms 2, Variants 78, PTMs 7 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .regulation of catalytic activity .dephosphorylation .signal transduction .protein phosphorylation .protein phosphatase type 4 regulator activity .protein phosphatase 4 complex Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 78 7 2014-09-19 protein level 2 65 7 2014-05-27 protein level 2 65 7 2014-02-25 protein level 2 65 7 2013-12-09 protein level 2 43 7 2013-11-01 protein level 2 40 5 2013-09-12 protein level 2 40 5 2013-08-17 protein level 2 40 5 2013-07-15 protein level 2 27 4 2013-06-11 protein level 2 27 4 2013-02-12 protein level 2 11 4 2012-12-20 protein level 2 10 4 2012-10-30 protein level 2 20 4 2012-10-07 protein level 2 20 2 2012-08-24 protein level 2 18 2 2012-07-28 protein level 2 18 2 2012-06-08 protein level 2 18 2 2012-05-07 protein level 2 18 2 2012-04-10 protein level 2 18 2 2012-01-13 protein level 2 6 2 2011-12-20 protein level 2 6 2 2011-11-11 protein level 2 6 2 2011-08-23 protein level 2 6 2 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q8TF05-1 1 37 0 106935.6563 NX_Q8TF05-2 1 37 0 105127.8094 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-1056262,EBI-1046072 PPP4C     .NIK/NF-kappaB signaling .dephosphorylation .regulation of double-strand break repair via homologous recombination .metal ion binding .protein serine/threonine phosphatase activity .NF-kappaB-inducing kinase activity .protein phosphatase 4 complex .plasma membrane .microtubule organizing center   + 3 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* ascites 50 bladder 66 blood 130 bone 97 bone marrow 82 brain 53 cervix 164 connective tissue 114 ear 124 embryonic tissue 140 esophagus 49 eye 52 heart 122 intestine 56 kidney 42 liver 53 lung 134 lymph node 200 mammary gland 238 mouth 151 muscle 75 nerve 193 ovary 118 pancreas 56 parathyroid 388 pharynx 24 pituitary gland 181 placenta 95 prostate 63 salivary gland 197 skin 66 spleen 37 stomach 52 testis 110 thymus 62 thyroid 64 trachea 308 umbilical cord 72 uterus 107 Health State Tissues TPM* normal 95 bladder carcinoma 56 breast (mammary gland) tumor 64 cervical tumor 231 chondrosarcoma 181 colorectal tumor 35 gastrointestinal tumor 59 germ cell tumor 72 glioma 27 head and neck tumor 112 kidney tumor 29 leukemia 95 liver tumor 62 lung tumor 77 lymphoma 55 non-neoplasia 165 ovarian tumor 144 pancreatic tumor 57 primitive neuroectodermal tumor of the CNS 47 prostate cancer 86 skin tumor 31 soft tissue/muscle tissue tumor 63 uterine tumor 33 Developmental Stage Tissues TPM* adult 111 embryoid body 200 blastocyst 32 neonate 128 fetus 120 juvenile 53 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 21 adrenal gland 21 appendix 25.6 bone marrow 32.6 cerebral cortex 17.5 colon 25.3 duodenum 32.2 esophagus 82.5 gallbladder 30.1 heart muscle 20.3 kidney 22.1 liver 11.5 lung 48.8 lymph node 18.3 ovary 21.6 pancreas 12 placenta 35.8 prostate 21.2 salivary gland 10.8 skin 33.2 small intestine 31.5 spleen 22 stomach 28.7 testis 48.3 thyroid gland 25.2 urinary bladder 40.8 Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*604908, gene) Protein phosphatase 4, regulatory subunit 1; PPP4R1 OMIM

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