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> Protein (NX_Q8TF05)
Protein (NX_Q8TF05)
Protein
Gene SymbolPPP4R1 to neXtProt (NX_Q8TF05)
DescriptionSerine/threonine-protein phosphatase 4 regulatory subunit 1
Chromosome18
Location18p11.22 (9546789 ~ 9615238) to Ensembl
Sequene Features : Isoforms 2, Variants 78, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of catalytic activity
.dephosphorylation
.signal transduction
.protein phosphorylation
.protein phosphatase type 4 regulator activity .protein phosphatase 4 complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 78 7
2014-09-19protein level
2 65 7
2014-05-27protein level
2 65 7
2014-02-25protein level
2 65 7
2013-12-09protein level
2 43 7
2013-11-01protein level
2 40 5
2013-09-12protein level
2 40 5
2013-08-17protein level
2 40 5
2013-07-15protein level
2 27 4
2013-06-11protein level
2 27 4
2013-02-12protein level
2 11 4
2012-12-20protein level
2 10 4
2012-10-30protein level
2 20 4
2012-10-07protein level
2 20 2
2012-08-24protein level
2 18 2
2012-07-28protein level
2 18 2
2012-06-08protein level
2 18 2
2012-05-07protein level
2 18 2
2012-04-10protein level
2 18 2
2012-01-13protein level
2 6 2
2011-12-20protein level
2 6 2
2011-11-11protein level
2 6 2
2011-08-23protein level
2 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TF05-1
1 37 0 106935.6563
NX_Q8TF05-2
1 37 0 105127.8094
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1056262,EBI-1046072 PPP4C  
  .NIK/NF-kappaB signaling
.dephosphorylation
.regulation of double-strand break repair via homologous recombination
.metal ion binding
.protein serine/threonine phosphatase activity
.NF-kappaB-inducing kinase activity
.protein phosphatase 4 complex
.plasma membrane
.microtubule organizing center
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder66
blood130
bone97
bone marrow82
brain53
cervix164
connective tissue114
ear124
embryonic tissue140
esophagus49
eye52
heart122
intestine56
kidney42
liver53
lung134
lymph node200
mammary gland238
mouth151
muscle75
nerve193
ovary118
pancreas56
parathyroid388
pharynx24
pituitary gland181
placenta95
prostate63
salivary gland197
skin66
spleen37
stomach52
testis110
thymus62
thyroid64
trachea308
umbilical cord72
uterus107
Health State
TissuesTPM*
normal95
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor231
chondrosarcoma181
colorectal tumor35
gastrointestinal tumor59
germ cell tumor72
glioma27
head and neck tumor112
kidney tumor29
leukemia95
liver tumor62
lung tumor77
lymphoma55
non-neoplasia165
ovarian tumor144
pancreatic tumor57
primitive neuroectodermal tumor of the CNS47
prostate cancer86
skin tumor31
soft tissue/muscle tissue tumor63
uterine tumor33
Developmental Stage
TissuesTPM*
adult111
embryoid body200
blastocyst32
neonate128
fetus120
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21
adrenal gland21
appendix25.6
bone marrow32.6
cerebral cortex17.5
colon25.3
duodenum32.2
esophagus82.5
gallbladder30.1
heart muscle20.3
kidney22.1
liver11.5
lung48.8
lymph node18.3
ovary21.6
pancreas12
placenta35.8
prostate21.2
salivary gland10.8
skin33.2
small intestine31.5
spleen22
stomach28.7
testis48.3
thyroid gland25.2
urinary bladder40.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604908, gene) Protein phosphatase 4, regulatory subunit 1; PPP4R1OMIM


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