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Protein |
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Gene Symbol | PPP4R1 to neXtProt (NX_Q8TF05) |
Description | Serine/threonine-protein phosphatase 4 regulatory subunit 1 |
Chromosome | 18 |
Location | 18p11.22 (9546789 ~ 9615238) to Ensembl |
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Sequene Features : Isoforms 2, Variants 78, PTMs 7 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.regulation of catalytic activity .dephosphorylation .signal transduction .protein phosphorylation |
.protein phosphatase type 4 regulator activity |
.protein phosphatase 4 complex |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 78 |
| 7 |
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2014-09-19 | | protein level | | | | | | | 2 |
| 65 |
| 7 |
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2014-05-27 | | protein level | | | | | | | 2 |
| 65 |
| 7 |
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2014-02-25 | | protein level | | | | | | | 2 |
| 65 |
| 7 |
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2013-12-09 | | protein level | | | | | | | 2 |
| 43 |
| 7 |
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2013-11-01 | | protein level | | | | | | | 2 |
| 40 |
| 5 |
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2013-09-12 | | protein level | | | | | | | 2 |
| 40 |
| 5 |
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2013-08-17 | | protein level | | | | | | | 2 |
| 40 |
| 5 |
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2013-07-15 | | protein level | | | | | | | 2 |
| 27 |
| 4 |
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2013-06-11 | | protein level | | | | | | | 2 |
| 27 |
| 4 |
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2013-02-12 | | protein level | | | | | | | 2 |
| 11 |
| 4 |
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2012-12-20 | | protein level | | | | | | | 2 |
| 10 |
| 4 |
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2012-10-30 | | protein level | | | | | | | 2 |
| 20 |
| 4 |
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2012-10-07 | | protein level | | | | | | | 2 |
| 20 |
| 2 |
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2012-08-24 | | protein level | | | | | | | 2 |
| 18 |
| 2 |
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2012-07-28 | | protein level | | | | | | | 2 |
| 18 |
| 2 |
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2012-06-08 | | protein level | | | | | | | 2 |
| 18 |
| 2 |
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2012-05-07 | | protein level | | | | | | | 2 |
| 18 |
| 2 |
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2012-04-10 | | protein level | | | | | | | 2 |
| 18 |
| 2 |
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2012-01-13 | | protein level | | | | | | | 2 |
| 6 |
| 2 |
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2011-12-20 | | protein level | | | | | | | 2 |
| 6 |
| 2 |
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2011-11-11 | | protein level | | | | | | | 2 |
| 6 |
| 2 |
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2011-08-23 | | protein level | | | | | | | 2 |
| 6 |
| 2 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-1056262,EBI-1046072 |
PPP4C |
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.NIK/NF-kappaB signaling .dephosphorylation .regulation of double-strand break repair via homologous recombination |
.metal ion binding .protein serine/threonine phosphatase activity .NF-kappaB-inducing kinase activity |
.protein phosphatase 4 complex .plasma membrane .microtubule organizing center + 3 more... |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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ascites | 50 | |
bladder | 66 | |
blood | 130 | |
bone | 97 | |
bone marrow | 82 | |
brain | 53 | |
cervix | 164 | |
connective tissue | 114 | |
ear | 124 | |
embryonic tissue | 140 | |
esophagus | 49 | |
eye | 52 | |
heart | 122 | |
intestine | 56 | |
kidney | 42 | |
liver | 53 | |
lung | 134 | |
lymph node | 200 | |
mammary gland | 238 | |
mouth | 151 | |
muscle | 75 | |
nerve | 193 | |
ovary | 118 | |
pancreas | 56 | |
parathyroid | 388 | |
pharynx | 24 | |
pituitary gland | 181 | |
placenta | 95 | |
prostate | 63 | |
salivary gland | 197 | |
skin | 66 | |
spleen | 37 | |
stomach | 52 | |
testis | 110 | |
thymus | 62 | |
thyroid | 64 | |
trachea | 308 | |
umbilical cord | 72 | |
uterus | 107 | |
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Health State | |
Tissues | TPM* | |
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normal | 95 | |
bladder carcinoma | 56 | |
breast (mammary gland) tumor | 64 | |
cervical tumor | 231 | |
chondrosarcoma | 181 | |
colorectal tumor | 35 | |
gastrointestinal tumor | 59 | |
germ cell tumor | 72 | |
glioma | 27 | |
head and neck tumor | 112 | |
kidney tumor | 29 | |
leukemia | 95 | |
liver tumor | 62 | |
lung tumor | 77 | |
lymphoma | 55 | |
non-neoplasia | 165 | |
ovarian tumor | 144 | |
pancreatic tumor | 57 | |
primitive neuroectodermal tumor of the CNS | 47 | |
prostate cancer | 86 | |
skin tumor | 31 | |
soft tissue/muscle tissue tumor | 63 | |
uterine tumor | 33 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 111 | |
embryoid body | 200 | |
blastocyst | 32 | |
neonate | 128 | |
fetus | 120 | |
juvenile | 53 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 21 | |
adrenal gland | 21 | |
appendix | 25.6 | |
bone marrow | 32.6 | |
cerebral cortex | 17.5 | |
colon | 25.3 | |
duodenum | 32.2 | |
esophagus | 82.5 | |
gallbladder | 30.1 | |
heart muscle | 20.3 | |
kidney | 22.1 | |
liver | 11.5 | |
lung | 48.8 | |
lymph node | 18.3 | |
ovary | 21.6 | |
pancreas | 12 | |
placenta | 35.8 | |
prostate | 21.2 | |
salivary gland | 10.8 | |
skin | 33.2 | |
small intestine | 31.5 | |
spleen | 22 | |
stomach | 28.7 | |
testis | 48.3 | |
thyroid gland | 25.2 | |
urinary bladder | 40.8 | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*604908, gene) Protein phosphatase 4, regulatory subunit 1; PPP4R1 | OMIM |
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