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> Protein (NX_Q8TF42)
Protein (NX_Q8TF42)
Protein
Gene SymbolUBASH3B to neXtProt (NX_Q8TF42)
DescriptionUbiquitin-associated and SH3 domain-containing protein B
Chromosome11
Location11q24.1 (122526383 ~ 122685181) to Ensembl
Sequene Features : Isoforms 1, Variants 78, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 78 9
2014-09-19protein level
1 60 9
2014-05-27protein level
1 60 9
2014-02-25protein level
1 60 9
2013-12-09protein level
1 51 9
2013-11-01protein level
1 48 9
2013-09-12protein level
1 48 9
2013-08-17protein level
1 48 9
2013-07-15protein level
1 22 3
2013-06-11protein level
1 22 3
2013-02-12protein level
1 12 3
2012-12-20protein level
1 12 3
2012-10-30protein level
1 14 3
2012-10-07protein level
1 14 3
2012-08-24protein level
1 13 3
2012-07-28protein level
1 13 3
2012-06-08protein level
1 14 3
2012-05-07protein level
1 10 3
2012-04-10protein level
1 10 3
2012-01-13protein level
1 7 3
2011-12-20protein level
1 7 3
2011-11-11protein level
1 7 3
2011-08-23protein level
1 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TF42-1
31 0 0 72649.2109
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1380492,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-1380492,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
3 EBI-1380492,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
4 EBI-1380492,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
5 EBI-1380492,EBI-10255185 SLC25A48  
  .transmembrane transport .N/A .integral component of membrane
.mitochondrial inner membrane
6 EBI-1380492,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
7 EBI-1380492,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
8 EBI-1380492,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
9 EBI-1380492,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
bone97
bone marrow102
brain47
connective tissue26
embryonic tissue18
esophagus49
intestine17
kidney142
liver77
lung50
lymph22
lymph node22
mammary gland13
muscle9
pancreas4
pharynx49
placenta67
skin75
spleen149
stomach10
testis48
thymus87
uterus86
vascular116
Health State
TissuesTPM*
normal43
breast (mammary gland) tumor21
chondrosarcoma60
colorectal tumor8
esophageal tumor57
gastrointestinal tumor8
germ cell tumor167
glioma27
head and neck tumor14
kidney tumor87
leukemia84
liver tumor135
lung tumor19
lymphoma13
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
skin tumor55
soft tissue/muscle tissue tumor39
uterine tumor22
Developmental Stage
TissuesTPM*
adult34
embryoid body57
neonate128
fetus26
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.6
adrenal gland1
appendix6.8
bone marrow6.6
cerebral cortex2.8
colon2.2
duodenum2.1
esophagus1.6
gallbladder2.4
lung8.1
lymph node6.6
pancreas1
placenta23.7
skin3
small intestine2.6
spleen17.7
stomach2.4
testis2.1
thyroid gland3.8
urinary bladder4.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
epididymisHigh
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
spleenHigh
stomach 1Medium
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609201, gene) Ubiquitin-associated and sh3 domain-containing protein b; UBASH3BOMIM


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