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> Protein (NX_Q8TF74)
Protein (NX_Q8TF74)
Protein
Gene SymbolWIPF2 to neXtProt (NX_Q8TF74)
DescriptionWAS/WASL-interacting protein family member 2
Chromosome17
Location17q21.1 (38375556 ~ 38440388) to Ensembl
Sequene Features : Isoforms 2, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
.small GTPase mediated signal transduction
.N/A .cytoskeleton
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 66 8
2014-09-19protein level
2 48 8
2014-05-27protein level
2 47 8
2014-02-25protein level
2 48 5
2013-12-09protein level
2 39 5
2013-11-01protein level
2 36 5
2013-09-12protein level
2 36 5
2013-08-17protein level
2 36 5
2013-07-15protein level
2 30 5
2013-06-11protein level
2 30 5
2013-02-12protein level
2 20 2
2012-12-20protein level
2 19 2
2012-10-30protein level
2 20 2
2012-10-07protein level
2 20 1
2012-08-24protein level
2 17 1
2012-07-28protein level
2 17 1
2012-06-08protein level
2 18 1
2012-05-07protein level
2 7 1
2012-04-10protein level
2 7 1
2012-01-13protein level
2 1 1
2011-12-20protein level
2 1 1
2011-11-11protein level
2 1 0
2011-08-23protein level
2 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8TF74-1
8 16 0 46260.0339
NX_Q8TF74-2
0 16 0 30820.9012
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2850112,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland151
ascites50
bladder66
blood49
bone69
bone marrow41
brain69
cervix123
connective tissue53
embryonic tissue75
eye62
heart44
intestine103
kidney80
larynx85
liver19
lung65
lymph45
lymph node55
mammary gland112
mouth136
muscle37
ovary78
pancreas84
parathyroid48
placenta42
prostate47
salivary gland49
skin37
spleen243
stomach20
testis39
thymus50
thyroid64
tonsil117
trachea38
umbilical cord145
uterus94
vascular96
Health State
TissuesTPM*
normal81
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor173
chondrosarcoma108
colorectal tumor151
gastrointestinal tumor42
germ cell tumor45
glioma74
head and neck tumor97
kidney tumor43
leukemia63
liver tumor20
lung tumor19
lymphoma27
non-neoplasia62
ovarian tumor91
pancreatic tumor57
primitive neuroectodermal tumor of the CNS31
prostate cancer38
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult80
embryoid body114
blastocyst16
neonate96
fetus132
infant127
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.8
adrenal gland8.7
appendix10.3
bone marrow13.2
cerebral cortex18
colon15
duodenum13.3
esophagus13.3
gallbladder11.3
heart muscle5.5
kidney12.6
liver5.1
lung13
lymph node9
ovary9.1
pancreas6.3
placenta14.1
prostate8.7
salivary gland6.3
skin13.2
small intestine13.7
spleen13
stomach14.1
testis9.2
thyroid gland11.3
urinary bladder11.4
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeMedium
gallbladderHigh
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungLow
nasopharynxLow
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleLow
skin 1Medium
skin 2Medium
small intestineMedium
stomach 1High
stomach 2Medium
testisLow
thyroid glandLow
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609692, gene) Was/wasl-interacting protein family, member 2; WIPF2OMIM


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