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> Protein (NX_Q8WTP8)
Protein (NX_Q8WTP8)
Protein
Gene SymbolAEN to neXtProt (NX_Q8WTP8)
DescriptionApoptosis-enhancing nuclease
Chromosome15
Location15q26.1 (89164527 ~ 89175513) to Ensembl
Sequene Features : Isoforms 2, Variants 51, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 51 1
2014-09-19protein level
2 41 1
2014-05-27protein level
2 41 1
2014-02-25protein level
2 41 1
2013-12-09protein level
2 29 1
2013-11-01protein level
2 24 1
2013-09-12protein level
2 24 1
2013-08-17protein level
2 24 1
2013-07-15protein level
2 20 0
2013-06-11protein level
2 20 0
2013-02-12protein level
2 15 0
2012-12-20protein level
2 15 0
2012-10-30protein level
2 17 0
2012-10-07protein level
2 17 0
2012-08-24protein level
2 17 0
2012-07-28protein level
2 17 0
2012-06-08protein level
2 20 0
2012-05-07protein level
2 20 0
2012-04-10protein level
2 20 0
2012-01-13protein level
2 13 0
2011-12-20protein level
2 13 0
2011-11-11protein level
2 13 0
2011-08-23protein level
2 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WTP8-1
1 14 0 36327.2892
NX_Q8WTP8-2
2 14 0 36472.4272
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8637627,EBI-740718 ZBTB43  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-8637627,EBI-8638511 RBMY1A1  
  .RNA splicing
.mRNA processing
.regulation of alternative mRNA splicing, via spliceosome
.mRNA binding
.nucleotide binding
.nucleus
3 EBI-8637627,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-8637627,EBI-489887 EMD  
  .cellular response to growth factor stimulus
.regulation of canonical Wnt signaling pathway
.negative regulation of fibroblast proliferation
  + 8 more...
.beta-tubulin binding
.actin binding
.nuclear membrane
.integral component of membrane
.membrane
  + 5 more...
5 EBI-8637627,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
6 EBI-8637627,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
7 EBI-8637627,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
8 EBI-8637627,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
9 EBI-8637627,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
10 EBI-8637627,EBI-8642021 RBMY1F  
  .RNA splicing
.spermatogenesis
.mRNA processing
.RNA binding
.nucleotide binding
.nucleus
11 EBI-8637627,EBI-1104907 GNPTAB  
  .carbohydrate phosphorylation
.cell differentiation
.N-glycan processing to lysosome
  + 2 more...
.calcium ion binding
.UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
.integral component of membrane
.Golgi apparatus
.nucleus
.Golgi membrane
12 EBI-8637627,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
13 EBI-8637627,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
14 EBI-8637627,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
15 EBI-8637627,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-8637627,EBI-741520 RALYL  
  .N/A .poly(A) RNA binding
.identical protein binding
.nucleotide binding
.N/A
17 EBI-8637627,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
18 EBI-8637627,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
19 EBI-8637627,EBI-751409 ZNF473  
  .mRNA 3'-end processing
.gene expression
.histone mRNA metabolic process
  + 4 more...
.metal ion binding
.DNA binding
.Cajal body
.nucleoplasm
20 EBI-8637627,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
21 EBI-8637627,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
22 EBI-8637627,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
23 EBI-8637627,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
24 EBI-8637627,EBI-1210473 ZNF317  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
25 EBI-8637627,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
26 EBI-8637627,EBI-711679 ZFP64  
  .positive regulation of mRNA splicing, via spliceosome
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
27 EBI-8637627,EBI-745730 ZFP64  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-8637627,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
29 EBI-8637627,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood40
bone41
bone marrow41
brain36
cervix268
connective tissue73
embryonic tissue122
eye67
heart33
intestine68
kidney9
liver19
lung71
lymph90
lymph node44
mammary gland46
mouth15
muscle65
ovary19
pancreas65
placenta49
prostate10
skin161
spleen37
stomach20
testis66
thyroid64
tonsil58
trachea38
uterus56
vascular38
Health State
TissuesTPM*
normal36
breast (mammary gland) tumor42
cervical tumor173
chondrosarcoma60
colorectal tumor35
gastrointestinal tumor67
germ cell tumor75
glioma55
head and neck tumor29
kidney tumor29
leukemia63
liver tumor41
lung tumor19
lymphoma124
non-neoplasia31
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS118
prostate cancer19
retinoblastoma215
skin tumor239
soft tissue/muscle tissue tumor143
uterine tumor33
Developmental Stage
TissuesTPM*
adult42
embryoid body85
blastocyst260
fetus46
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.9
adrenal gland9.8
appendix12.3
bone marrow10.9
cerebral cortex3.4
colon11
duodenum5.2
esophagus8.6
gallbladder14.6
heart muscle2.7
kidney3.4
liver5.1
lung5.7
lymph node13.7
ovary5.7
pancreas9.4
placenta7.2
prostate7.1
salivary gland4.2
skin3.5
small intestine5.4
spleen10.7
stomach7.5
testis10.9
thyroid gland13
urinary bladder10.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610177, gene) Interferon-stimulated exonuclease gene 20-kd-like 1; ISG20L1OMIM


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