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> Protein (NX_Q8WUK0)
Protein (NX_Q8WUK0)
Protein
Gene SymbolPTPMT1 to neXtProt (NX_Q8WUK0)
DescriptionPhosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Chromosome11
Location11p11.2 (47586982 ~ 47595013) to Ensembl
Sequene Features : Isoforms 3, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.inositol phosphate dephosphorylation
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 4 more...
.phosphatidylglycerophosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.integral component of mitochondrial inner membrane
.mitochondrion
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 26 0
2014-09-19protein level
3 23 0
2014-05-27protein level
3 21 0
2014-02-25protein level
3 21 0
2013-12-09protein level
3 16 0
2013-11-01protein level
3 16 0
2013-09-12protein level
3 16 0
2013-08-17protein level
3 16 0
2013-07-15protein level
3 10 0
2013-06-11protein level
3 10 0
2013-02-12protein level
3 5 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 5 0
2012-10-07protein level
2 5 0
2012-08-24protein level
2 5 0
2012-07-28protein level
2 5 0
2012-06-08protein level
2 5 0
2012-05-07protein level
2 2 0
2012-04-10protein level
2 2 0
2012-01-13protein level
2 1 0
2011-12-20protein level
2 1 0
2011-11-11protein level
2 1 0
2011-08-23protein level
2 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WUK0-1
4 8 0 22829.0819
NX_Q8WUK0-2
1 8 0 15679.3733
NX_Q8WUK0-3
4 3 0 16448.6115
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7199479,EBI-10178530 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
2 EBI-7199479,EBI-10196781 KRTAP2-3  
  .N/A .N/A .keratin filament
3 EBI-7199479,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-7199479,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
5 EBI-7199479,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
6 EBI-7199479,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
7 EBI-7199479,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-7199479,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
9 EBI-7199479,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-7199479,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
11 EBI-7199479,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
12 EBI-7199479,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
13 EBI-7199479,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood8
bone13
brain26
cervix82
connective tissue60
embryonic tissue4
esophagus49
eye38
intestine17
kidney52
liver29
lung5
lymph node22
mammary gland19
muscle9
nerve64
ovary9
pancreas14
placenta28
prostate36
skin23
testis110
uterus17
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor10
cervical tumor115
chondrosarcoma36
colorectal tumor8
esophageal tumor57
gastrointestinal tumor8
germ cell tumor30
glioma46
kidney tumor43
leukemia21
liver tumor20
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor55
uterine tumor22
Developmental Stage
TissuesTPM*
adult27
embryoid body14
neonate32
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue33.3
adrenal gland34
appendix17.2
bone marrow23
cerebral cortex29.1
colon25.5
duodenum20.2
esophagus16.4
gallbladder20.6
heart muscle11.9
kidney34.2
liver16.4
lung28.5
lymph node21.4
ovary16.6
pancreas19.6
placenta22.6
prostate28.7
salivary gland31
skin14.6
small intestine19.1
spleen19.5
stomach26.2
testis56.3
thyroid gland25.6
urinary bladder20.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609538, gene) Protein-tyrosine phosphatase, mitochondrial, 1; PTPMT1OMIM


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