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> Protein (NX_Q8WV28)
Protein (NX_Q8WV28)
Protein
Gene SymbolBLNK to neXtProt (NX_Q8WV28)
DescriptionB-cell linker protein
Chromosome10
Location10q24.1 (97951458 ~ 98031344) to Ensembl
Sequene Features : Isoforms 3, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular signal transduction
.B cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 64 6
2014-09-19protein level
3 43 6
2014-05-27protein level
3 43 6
2014-02-25protein level
3 43 6
2013-12-09protein level
3 31 6
2013-11-01protein level
3 26 6
2013-09-12protein level
3 26 6
2013-08-17protein level
3 26 6
2013-07-15protein level
3 15 6
2013-06-11protein level
3 15 6
2013-02-12protein level
3 9 15
2012-12-20protein level
2 9 10
2012-10-30protein level
2 11 10
2012-10-07protein level
2 11 5
2012-08-24protein level
2 9 5
2012-07-28protein level
2 9 5
2012-06-08protein level
2 14 5
2012-05-07protein level
2 14 5
2012-04-10protein level
2 14 5
2012-01-13protein level
2 8 5
2011-12-20protein level
2 8 5
2011-11-11protein level
2 8 5
2011-08-23protein level
2 8 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WV28-1
0 17 0 50435.2345
NX_Q8WV28-2
0 16 0 48199.1503
NX_Q8WV28-3
1 15 0 44423.0605
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2623522,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
2 EBI-2623522,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
3 EBI-2623522,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-2623522,EBI-624835 BTK  
  .apoptotic signaling pathway
.cellular response to molecule of fungal origin
.positive regulation of NF-kappaB transcription factor activity
  + 28 more...
.metal ion binding
.identical protein binding
.phosphatidylinositol-3,4,5-trisphosphate binding
  + 3 more...
.perinuclear region of cytoplasm
.membrane raft
.intracellular membrane-bounded organelle
  + 7 more...
5 EBI-2623522,EBI-298152 CD2AP  
  .regulation of actin cytoskeleton reorganization
.positive regulation of protein localization to nucleus
.cell division
  + 5 more...
.SH3 domain binding
.structural constituent of cytoskeleton
.extracellular exosome
.filamentous actin
.actin cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood24
brain2
connective tissue6
intestine25
kidney37
lung8
lymph45
lymph node89
mammary gland6
muscle9
pancreas18
parathyroid48
pharynx196
placenta21
spleen37
stomach20
testis2
thyroid21
tonsil176
uterus12
Health State
TissuesTPM*
normal13
breast (mammary gland) tumor10
colorectal tumor35
germ cell tumor3
head and neck tumor14
kidney tumor29
leukemia21
lymphoma110
pancreatic tumor19
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult10
fetus8
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.2
adrenal gland3.8
appendix30.2
bone marrow7.3
cerebral cortex4.3
colon18.6
duodenum40.1
esophagus32.6
gallbladder13.1
kidney20.5
liver19.1
lung5.6
lymph node60.2
ovary1.6
pancreas6.3
placenta7.4
prostate8.6
salivary gland6.1
skin8
small intestine38.1
spleen56
stomach33.7
testis1.9
thyroid gland14.5
urinary bladder18.9
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowLow
breastLow
bronchusLow
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonLow
duodenumLow
epididymisLow
esophagusLow
gallbladderLow
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
lymph nodeHigh
nasopharynxLow
oral mucosaLow
ovaryLow
pancreasLow
placentaLow
rectumLow
seminal vesicleLow
skin 1Low
skin 2Low
small intestineLow
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1Low
stomach 2Low
testisLow
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604515, gene) B-cell linker protein; BLNKOMIM
2(#613502, phenotype) Agammaglobulinemia 4, autosomal recessive; AGM4OMIM


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