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> Protein (NX_Q8WV41)
Protein (NX_Q8WV41)
Protein
Gene SymbolSNX33 to neXtProt (NX_Q8WV41)
DescriptionSorting nexin-33
Chromosome15
Location15q24.2 (75940247 ~ 75954642) to Ensembl
Sequene Features : Isoforms 1, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein localization to cell surface
.negative regulation of protein localization to cell surface
.membrane tubulation
  + 12 more...
.identical protein binding
.phosphatidylinositol binding
.cytoplasmic vesicle membrane
.extrinsic component of membrane
.cytoplasmic membrane-bounded vesicle
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 64 1
2014-09-19protein level
1 51 1
2014-05-27protein level
1 51 1
2014-02-25protein level
1 50 1
2013-12-09protein level
1 38 1
2013-11-01protein level
1 37 1
2013-09-12protein level
1 37 1
2013-08-17protein level
1 37 1
2013-07-15protein level
1 27 1
2013-06-11protein level
1 27 1
2013-02-12protein level
1 11 2
2012-12-20protein level
1 11 2
2012-10-30protein level
1 13 2
2012-10-07protein level
1 13 2
2012-08-24protein level
1 12 2
2012-07-28protein level
1 12 2
2012-06-08protein level
1 12 2
2012-05-07protein level
1 10 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 2 2
2011-12-20protein level
1 2 2
2011-11-11protein level
1 2 2
2011-08-23protein level
1 2 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WV41-1
24 0 0 65222.9908
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2481535,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
2 EBI-2481535,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
3 EBI-2481535,EBI-713135 DNM1  
  .clathrin-mediated endocytosis
.ephrin receptor signaling pathway
.receptor internalization
  + 4 more...
.poly(A) RNA binding
.identical protein binding
.protein kinase binding
  + 2 more...
.extracellular exosome
.membrane coat
.plasma membrane
.microtubule
4 EBI-2481535,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
5 EBI-2481535,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
bladder66
bone27
brain1
cervix20
connective tissue33
embryonic tissue23
eye19
heart11
intestine17
kidney28
liver4
lung29
mammary gland26
muscle9
ovary9
pancreas9
placenta17
prostate36
salivary gland49
skin33
testis2
thyroid42
uterus38
Health State
TissuesTPM*
normal12
breast (mammary gland) tumor21
chondrosarcoma72
colorectal tumor8
germ cell tumor15
glioma9
head and neck tumor22
kidney tumor43
liver tumor10
lung tumor19
non-neoplasia10
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer48
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult19
embryoid body14
blastocyst48
neonate64
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.9
adrenal gland12.5
appendix6.7
cerebral cortex4.8
colon11.2
duodenum9.9
esophagus18.3
gallbladder15.4
heart muscle8.5
kidney9.7
liver8.5
lung14.8
lymph node7.9
ovary18.6
pancreas7.8
placenta11.2
prostate14.5
salivary gland10.7
skin17.8
small intestine10.9
spleen8.5
stomach13.2
testis3.7
thyroid gland9.7
urinary bladder14.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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