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> Protein (NX_Q8WV44)
Protein (NX_Q8WV44)
Protein
Gene SymbolTRIM41 to neXtProt (NX_Q8WV44)
DescriptionE3 ubiquitin-protein ligase TRIM41
Chromosome5
Location5q35.3 (180649499 ~ 180662809) to Ensembl
Sequene Features : Isoforms 4, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 70 6
2014-09-19protein level
4 60 6
2014-05-27protein level
4 60 6
2014-02-25protein level
4 59 6
2013-12-09protein level
4 45 6
2013-11-01protein level
4 44 6
2013-09-12protein level
4 44 6
2013-08-17protein level
4 44 6
2013-07-15protein level
4 33 2
2013-06-11protein level
4 33 2
2013-02-12protein level
4 22 6
2012-12-20protein level
4 22 6
2012-10-30protein level
4 20 6
2012-10-07protein level
4 20 2
2012-08-24protein level
4 19 2
2012-07-28protein level
4 19 2
2012-06-08protein level
4 4 2
2012-05-07protein level
4 4 2
2012-04-10protein level
4 4 2
2012-01-13protein level
4 4 2
2011-12-20protein level
4 7 2
2011-11-11protein level
4 7 1
2011-08-23protein level
4 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WV44-1
0 30 0 71624.4871
NX_Q8WV44-2
1 22 0 59263.9621
NX_Q8WV44-3
0 11 0 23592.9037
NX_Q8WV44-4
0 18 0 43463.4318
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-725997,EBI-1210503 CHD2  
  .hematopoietic stem cell differentiation
.DNA duplex unwinding
.chromatin modification
  + 4 more...
.poly(A) RNA binding
.histone binding
.ATP binding
  + 3 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.nucleolus
  + 2 more...
2 EBI-725997,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
3 EBI-725997,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
4 EBI-725997,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
5 EBI-725997,EBI-373403 TOP3B  
  .chromosome segregation
.DNA topological change
.poly(A) RNA binding
.DNA topoisomerase type I activity
.DNA topoisomerase activity
.DNA binding
.nucleoplasm
.nucleus
.condensed chromosome
6 EBI-725997,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
7 EBI-725997,EBI-2841331 ZNF26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
8 EBI-725997,EBI-347451 CSNK2A2  
  .mitotic spindle checkpoint
.Wnt signaling pathway
.axon guidance
  + 4 more...
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
9 EBI-725997,EBI-10213071 ZNF138  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
10 EBI-725997,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
11 EBI-725997,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
12 EBI-725997,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
13 EBI-725997,EBI-7115319 ZNF266  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
14 EBI-725997,EBI-3920053 ZSCAN26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.nucleic acid binding
.nucleus
15 EBI-725997,EBI-7236323 ZFP2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
16 EBI-725997,EBI-7233259 ZNF329  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
17 EBI-725997,EBI-744506 FAM124A  
  .N/A .N/A .N/A
18 EBI-725997,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
19 EBI-725997,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
20 EBI-725997,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
21 EBI-725997,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
22 EBI-725997,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
23 EBI-725997,EBI-745276 ZNF670  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
24 EBI-725997,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
25 EBI-725997,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
26 EBI-725997,EBI-5464419 PUS7L  
  .tRNA processing
.pseudouridine synthesis
.pseudouridine synthase activity
.RNA binding
.N/A
27 EBI-725997,EBI-473834 MAGEH1  
  .apoptotic process .N/A .cytoplasm
28 EBI-725997,EBI-711679 ZFP64  
  .positive regulation of mRNA splicing, via spliceosome
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
29 EBI-725997,EBI-745730 ZFP64  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
30 EBI-725997,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
31 EBI-725997,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
32 EBI-725997,EBI-1105370 ZNF490  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
33 EBI-725997,EBI-10281938 ZSCAN21  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.metal ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone55
brain6
cervix20
connective tissue13
embryonic tissue23
esophagus49
eye47
heart22
intestine30
kidney18
liver4
lung23
lymph node11
mammary gland13
muscle9
nerve128
ovary9
pancreas79
pituitary gland60
placenta35
prostate42
skin14
stomach31
testis43
thymus138
thyroid21
trachea19
uterus4
Health State
TissuesTPM*
normal5
bladder carcinoma56
cervical tumor28
chondrosarcoma60
colorectal tumor17
esophageal tumor57
gastrointestinal tumor16
germ cell tumor7
glioma65
kidney tumor58
leukemia21
lung tumor38
lymphoma27
non-neoplasia10
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer48
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult33
embryoid body14
blastocyst32
fetus19
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.1
adrenal gland10.2
appendix13.6
bone marrow12
cerebral cortex13.8
colon8.4
duodenum11.5
esophagus8.3
gallbladder8.8
heart muscle9.8
kidney14.4
liver6.9
lung10.8
lymph node13.1
ovary7.2
pancreas6.3
placenta8.9
prostate9.9
salivary gland8.7
skin11.9
small intestine11.2
spleen14.8
stomach13.2
testis24.4
thyroid gland14
urinary bladder8.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610530, gene) Tripartite motif-containing 41; TRIM41OMIM


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2014-2019 (C) Yonsei Proteome Research Center