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> Protein (NX_Q8WVD3)
Protein (NX_Q8WVD3)
Protein
Gene SymbolRNF138 to neXtProt (NX_Q8WVD3)
DescriptionE3 ubiquitin-protein ligase RNF138
Chromosome18
Location18q12.1 (29671818 ~ 29711524) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination
.Wnt signaling pathway
.protein kinase binding
.ligase activity
.zinc ion binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 6
2014-09-19protein level
2 24 6
2014-05-27protein level
2 23 6
2014-02-25protein level
2 23 6
2013-12-09protein level
2 23 6
2013-11-01protein level
2 23 6
2013-09-12protein level
2 23 6
2013-08-17protein level
2 23 6
2013-07-15protein level
2 14 0
2013-06-11protein level
2 14 0
2013-02-12protein level
2 5 3
2012-12-20protein level
2 5 3
2012-10-30protein level
2 5 3
2012-10-07protein level
2 5 2
2012-08-24protein level
2 4 2
2012-07-28protein level
2 4 2
2012-06-08protein level
2 6 2
2012-05-07protein level
2 4 2
2012-04-10protein level
2 4 2
2012-01-13protein level
2 7 2
2011-12-20protein level
2 7 2
2011-11-11protein level
2 7 2
2011-08-23protein level
2 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WVD3-1
4 6 0 28174.1196
NX_Q8WVD3-2
1 6 0 17250.9011
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749039,EBI-473850 UBE2K  
  .protein K48-linked ubiquitination
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.intermediate filament cytoskeleton
.actin cytoskeleton
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder167
blood57
bone27
bone marrow61
brain49
cervix61
connective tissue67
embryonic tissue14
esophagus198
eye33
heart11
intestine60
kidney23
liver34
lung8
lymph node22
mammary gland52
mouth60
ovary9
pancreas23
pharynx24
pituitary gland60
placenta7
prostate21
salivary gland49
skin18
spleen37
testis278
thymus62
trachea173
uterus30
Health State
TissuesTPM*
normal33
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor86
colorectal tumor62
esophageal tumor231
germ cell tumor41
glioma27
head and neck tumor7
kidney tumor29
leukemia42
liver tumor41
lymphoma69
non-neoplasia62
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
prostate cancer28
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor95
Developmental Stage
TissuesTPM*
adult30
embryoid body28
blastocyst16
fetus26
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.5
adrenal gland7.7
appendix17.6
bone marrow50.9
cerebral cortex9.2
colon20.1
duodenum14.7
esophagus11.8
gallbladder14.5
heart muscle5.1
kidney8.2
liver10.4
lung13.1
lymph node21.6
ovary12.6
pancreas6.8
placenta12.5
prostate10.1
salivary gland7.5
skin7.6
small intestine15.6
spleen17.7
stomach13.8
testis64.9
thyroid gland11.7
urinary bladder13
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 2Low
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilLow
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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