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> Protein (NX_Q8WVJ9)
Protein (NX_Q8WVJ9)
Protein
Gene SymbolTWIST2 to neXtProt (NX_Q8WVJ9)
DescriptionTwist-related protein 2
Chromosome2
Location2q37.3 (239756673 ~ 239795893) to Ensembl
Sequene Features : Isoforms 1, Variants 4, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cornea development in camera-type eye
.face morphogenesis
.embryonic cranial skeleton morphogenesis
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.RNA polymerase II transcription factor binding transcription factor activity
.cytoplasm
.transcription factor complex
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 4 0
2014-09-19protein level
1 3 0
2014-05-27protein level
1 3 0
2014-02-25protein level
1 3 0
2013-12-09protein level
1 3 0
2013-11-01protein level
1 3 0
2013-09-12protein level
1 3 0
2013-08-17protein level
1 3 0
2013-07-15protein level
1 0 0
2013-06-11protein level
1 0 0
2013-02-12protein level
1 0 0
2012-12-20protein level
1 0 0
2012-10-30protein level
1 0 0
2012-10-07protein level
1 0 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WVJ9-1
5 0 4 18113.0867
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1797313,EBI-1646991 ETS2  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.cell differentiation
  + 4 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.nucleoplasm
.nucleus
2 EBI-1797313,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
3 EBI-1797313,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
4 EBI-1797313,EBI-1573056 CCM2  
  .endothelial tube morphogenesis
.blood vessel endothelial cell differentiation
.pericardium development
  + 9 more...
.N/A .protein complex
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
cervix20
connective tissue26
embryonic tissue4
eye4
heart44
liver9
lung5
mammary gland6
ovary9
pancreas28
placenta14
prostate10
skin33
uterus4
Health State
TissuesTPM*
normal3
cervical tumor28
chondrosarcoma24
lung tumor19
ovarian tumor13
pancreatic tumor9
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult5
embryoid body28
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.7
colon1.9
ovary1.5
placenta1.1
prostate3.8
skin2.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#227260, phenotype) Setleis syndromeOMIM
2(*607556, gene) Twist, drosophila, homolog of, 2; TWIST2OMIM


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