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> Protein (NX_Q8WVV9)
Protein (NX_Q8WVV9)
Protein
Gene SymbolHNRNPLL to neXtProt (NX_Q8WVV9)
DescriptionHeterogeneous nuclear ribonucleoprotein L-like
Chromosome2
Location2p22.1 (38789120 ~ 38830728) to Ensembl
Sequene Features : Isoforms 5, Variants 10, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of RNA splicing
.mRNA processing
.poly(A) RNA binding
.mRNA binding
.nucleotide binding
.ribonucleoprotein complex
.membrane
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 10 8
2014-09-19protein level
5 22 8
2014-05-27protein level
5 22 8
2014-02-25protein level
4 22 8
2013-12-09protein level
4 15 8
2013-11-01protein level
4 14 5
2013-09-12protein level
4 14 5
2013-08-17protein level
4 14 5
2013-07-15protein level
4 10 5
2013-06-11protein level
4 10 5
2013-02-12protein level
4 5 8
2012-12-20protein level
4 6 8
2012-10-30protein level
4 6 8
2012-10-07protein level
4 6 2
2012-08-24protein level
4 4 2
2012-07-28protein level
4 4 2
2012-06-08protein level
4 0 2
2012-05-07protein level
4 0 2
2012-04-10protein level
4 0 2
2012-01-13protein level
4 0 2
2011-12-20protein level
4 1 2
2011-11-11protein level
4 1 1
2011-08-23protein level
4 1 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WVV9-1
0 30 0 60044.7051
NX_Q8WVV9-2
1 15 0 31212.3618
NX_Q8WVV9-3
0 14 0 30734.1839
NX_Q8WVV9-4
0 29 0 59609.5824
NX_Q8WVV9-5
1 27 0 56430.9057
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-535849,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
2 EBI-535849,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
3 EBI-535849,EBI-998198 BOLL  
  .positive regulation of translational initiation
.cell differentiation
.spermatogenesis
  + 2 more...
.translation activator activity
.RNA binding
.nucleotide binding
.cytoplasm
4 EBI-535849,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
5 EBI-535849,EBI-945792 QKI  
  .3'-UTR-mediated mRNA destabilization
.mRNA transport
.long-chain fatty acid biosynthetic process
  + 8 more...
.poly(A) RNA binding
.mRNA binding
.cytoplasm
.nucleus
6 EBI-535849,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
7 EBI-535849,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
8 EBI-535849,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites50
bladder167
blood32
bone13
bone marrow41
brain56
connective tissue53
ear124
embryonic tissue46
esophagus49
eye38
intestine38
kidney47
liver24
lung41
lymph node33
mammary gland33
mouth30
muscle18
nerve64
ovary29
pancreas42
parathyroid48
placenta74
prostate26
salivary gland49
skin28
spleen18
stomach73
testis105
thymus50
trachea38
umbilical cord72
uterus60
vascular58
Health State
TissuesTPM*
normal47
bladder carcinoma170
breast (mammary gland) tumor53
chondrosarcoma36
colorectal tumor35
esophageal tumor57
gastrointestinal tumor59
germ cell tumor102
glioma83
head and neck tumor14
kidney tumor58
leukemia10
liver tumor31
lung tumor29
lymphoma27
non-neoplasia31
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS62
prostate cancer9
retinoblastoma43
skin tumor23
soft tissue/muscle tissue tumor31
uterine tumor66
Developmental Stage
TissuesTPM*
adult43
embryoid body57
blastocyst48
neonate96
fetus53
infant85
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.2
adrenal gland22.8
appendix18.1
bone marrow30.7
cerebral cortex19.2
colon19
duodenum17.1
esophagus18
gallbladder21.6
heart muscle13.7
kidney17.2
liver8.1
lung19.9
lymph node19.2
ovary22.3
pancreas9.5
placenta18.1
prostate22.6
salivary gland14.9
skin9.5
small intestine18.2
spleen12.3
stomach18.1
testis38.5
thyroid gland25.7
urinary bladder21.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611208, gene) Heterogeneous nuclear ribonucleoprotein l-like; HNRNPLLOMIM


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