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> Protein (NX_Q8WWB5)
Protein (NX_Q8WWB5)
Protein
Gene SymbolPIH1D2 to neXtProt (NX_Q8WWB5)
DescriptionPIH1 domain-containing protein 2
Chromosome11
Location11q23.1 (111934734 ~ 111944998) to Ensembl
Sequene Features : Isoforms 3, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .Ral GTPase binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 37 0
2014-09-19protein level
3 28 0
2014-05-27transcript level
3 28 0
2014-02-25transcript level
1 26 0
2013-12-09transcript level
1 22 0
2013-11-01transcript level
1 22 0
2013-09-12transcript level
1 22 0
2013-08-17transcript level
1 22 0
2013-07-15transcript level
1 17 0
2013-06-11transcript level
1 17 0
2013-02-12transcript level
1 8 0
2012-12-20transcript level
1 8 0
2012-10-30transcript level
1 8 0
2012-10-07transcript level
1 8 0
2012-08-24transcript level
1 6 0
2012-07-28transcript level
1 6 0
2012-06-08transcript level
1 6 0
2012-05-07transcript level
1 6 0
2012-04-10transcript level
1 6 0
2012-01-13transcript level
1 3 0
2011-12-20transcript level
1 3 0
2011-11-11transcript level
1 3 0
2011-08-23transcript level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WWB5-1
3 11 0 35933.6435
NX_Q8WWB5-2
1 11 0 32668.7937
NX_Q8WWB5-3
1 11 0 31025.9417
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10232538,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
2 EBI-10232538,EBI-10176396 KRTAP12-4  
  .N/A .N/A .keratin filament
3 EBI-10232538,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
4 EBI-10232538,EBI-10175826 ITGB3BP  
  .apoptotic signaling pathway
.cell division
.neurotrophin TRK receptor signaling pathway
  + 10 more...
.protein C-terminus binding
.signal transducer activity
.membrane
.cytosol
.cytoplasm
  + 3 more...
5 EBI-10232538,EBI-10232522 EIF4A2  
  .negative regulation of RNA-directed RNA polymerase activity
.cellular protein metabolic process
.cytokine-mediated signaling pathway
  + 8 more...
.poly(A) RNA binding
.ATPase activity
.ATP binding
  + 3 more...
.perinuclear region of cytoplasm
.eukaryotic translation initiation factor 4F complex
.cytosol
.nucleolus
6 EBI-10232538,EBI-465363 DPH3  
  .positive regulation of binding
.negative regulation of protein secretion
.cellular protein metabolic process
  + 2 more...
.metal ion binding .cytosol
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-10232538,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
8 EBI-10232538,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain5
eye4
intestine4
kidney18
liver4
lung5
mammary gland6
pharynx49
pituitary gland60
placenta17
prostate10
testis48
trachea19
umbilical cord145
uterus4
Health State
TissuesTPM*
normal10
breast (mammary gland) tumor10
germ cell tumor18
leukemia10
prostate cancer9
uterine tumor11
Developmental Stage
TissuesTPM*
adult9
neonate64
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.1
cerebral cortex1.3
esophagus1.7
gallbladder1.9
heart muscle1.4
kidney4.1
lung4.2
ovary1.7
prostate1.1
salivary gland1.2
testis58.8
thyroid gland6.5
urinary bladder1.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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