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> Protein (NX_Q8WWW0)
Protein (NX_Q8WWW0)
Protein
Gene SymbolRASSF5 to neXtProt (NX_Q8WWW0)
DescriptionRas association domain-containing protein 5
Chromosome1
Location1q32.1 (206680879 ~ 206762616) to Ensembl
Sequene Features : Isoforms 3, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 44 1
2014-09-19protein level
3 32 1
2014-05-27protein level
3 31 1
2014-02-25protein level
3 31 1
2013-12-09protein level
3 27 1
2013-11-01protein level
3 24 1
2013-09-12protein level
3 24 1
2013-08-17protein level
3 24 1
2013-07-15protein level
4 17 1
2013-06-11protein level
4 17 1
2013-02-12protein level
4 11 8
2012-12-20protein level
4 10 8
2012-10-30protein level
4 10 8
2012-10-07protein level
4 10 3
2012-08-24protein level
4 10 3
2012-07-28protein level
4 10 3
2012-06-08protein level
4 10 3
2012-05-07protein level
4 7 3
2012-04-10protein level
4 7 3
2012-01-13protein level
4 2 3
2011-12-20protein level
4 2 3
2011-11-11protein level
4 2 3
2011-08-23protein level
4 2 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WWW0-1
0 21 0 47060.5025
NX_Q8WWW0-2
2 10 0 30339.7185
NX_Q8WWW0-3
1 17 0 37409.4139
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-367390,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-367390,EBI-350145 HRAS  
  .positive regulation of miRNA metabolic process
.positive regulation of actin cytoskeleton reorganization
.positive regulation of ruffle assembly
  + 53 more...
.protein C-terminus binding
.GTP binding
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 4 more...
3 EBI-367390,EBI-713992 RABIF  
  .membrane fusion
.positive regulation of GTPase activity
.protein transport
.small GTPase mediated signal transduction
.zinc ion binding
.guanyl-nucleotide exchange factor activity
.N/A
4 EBI-367390,EBI-960081 RASSF2  
  .negative regulation of NIK/NF-kappaB signaling
.homeostasis of number of cells
.bone remodeling
  + 6 more...
.N/A .cytoplasm
.nucleus
5 EBI-367390,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
6 EBI-367390,EBI-358143 RAP1B  
  .negative regulation of synaptic vesicle exocytosis
.regulation of establishment of cell polarity
.regulation of cell junction assembly
  + 9 more...
.protein complex binding
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.membrane
.cell-cell junction
  + 4 more...
7 EBI-367390,EBI-750871 RAP2B  
  .platelet aggregation
.regulation of protein tyrosine kinase activity
.Rap protein signal transduction
  + 4 more...
.GDP binding
.GTP binding
.extracellular exosome
.recycling endosome membrane
.membrane raft
  + 5 more...
8 EBI-960502,EBI-491414 RAP1A  
  .positive regulation of vasculogenesis
.negative regulation of synaptic vesicle exocytosis
.cellular response to nerve growth factor stimulus
  + 18 more...
.protein complex binding
.Rap guanyl-nucleotide exchange factor activity
.protein transporter activity
  + 2 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 7 more...
9 EBI-367390,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
10 EBI-367390,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
11 EBI-367390,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-367390,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
13 EBI-367390,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
14 EBI-367390,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
15 EBI-367390,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-367390,EBI-6952711 MYLIP  
  .positive regulation of protein catabolic process
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cholesterol homeostasis
  + 6 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
  + 2 more...
.extrinsic component of membrane
.plasma membrane
.cytoskeleton
  + 2 more...
17 EBI-367390,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
18 EBI-367390,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
19 EBI-367390,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
20 EBI-367390,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
21 EBI-367390,EBI-307461 BTRC  
  .cellular response to organic cyclic compound
.regulation of proteasomal protein catabolic process
.branching involved in mammary gland duct morphogenesis
  + 28 more...
.ligase activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytosol
.nucleoplasm
22 EBI-367390,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood106
bone marrow41
brain25
cervix61
connective tissue46
ear124
embryonic tissue4
esophagus49
eye14
heart11
intestine12
kidney9
liver24
lung59
lymph22
lymph node100
mammary gland13
mouth105
muscle18
ovary9
pancreas60
pharynx122
placenta7
prostate10
skin9
spleen262
stomach20
testis9
thymus326
thyroid64
tonsil117
trachea173
uterus34
Health State
TissuesTPM*
normal45
breast (mammary gland) tumor10
cervical tumor86
chondrosarcoma48
colorectal tumor17
esophageal tumor57
gastrointestinal tumor25
germ cell tumor41
head and neck tumor74
leukemia105
liver tumor41
lymphoma41
non-neoplasia41
ovarian tumor13
pancreatic tumor19
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult40
neonate32
fetus43
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland15.2
appendix56.2
bone marrow81.8
cerebral cortex6.1
colon10.4
duodenum9.9
esophagus33.8
gallbladder25.3
heart muscle6.2
kidney3.1
liver7.9
lung28.9
lymph node72.6
ovary4.4
pancreas5.8
placenta4.6
prostate8.4
salivary gland26.3
skin19
small intestine12.4
spleen62.9
stomach21.2
testis2.4
thyroid gland7
urinary bladder35.4
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowHigh
breastLow
bronchusLow
cerebral cortexMedium
colonLow
endometrium 2Low
epididymisMedium
esophagusLow
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyLow
lateral ventricleMedium
lungHigh
lymph nodeMedium
nasopharynxMedium
parathyroid glandLow
rectumLow
salivary glandLow
skin 1Low
skin 2Low
soft tissue 1Low
soft tissue 2Low
stomach 1High
stomach 2Medium
testisLow
tonsilMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607020, gene) Ras association domain family protein 5; RASSF5OMIM


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